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依托泊苷掺入骆驼奶磷脂脂质体后，在小鼠模型中对纤维肉瘤的活性增强。

Etoposide incorporated into camel milk phospholipids liposomes shows increased activity against fibrosarcoma in a mouse model.

作者信息

Maswadeh Hamzah M, Aljarbou Ahmad N, Alorainy Mohammed S, Alsharidah Mansour S, Khan Masood A

机构信息

Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraidah 51412, Saudi Arabia.

Department of Pharmacology & Therapeutics, College of Medicine, Qassim University, Buraydah, Saudi Arabia.

出版信息

Biomed Res Int. 2015;2015:743051. doi: 10.1155/2015/743051. Epub 2015 Mar 2.

DOI:10.1155/2015/743051
PMID:25821817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4363510/
Abstract

Phospholipids were isolated from camel milk and identified by using high performance liquid chromatography and gas chromatography-mass spectrometry (GC/MS). Anticancer drug etoposide (ETP) was entrapped in liposomes, prepared from camel milk phospholipids, to determine its activity against fibrosarcoma in a murine model. Fibrosarcoma was induced in mice by injecting benzopyrene (BAP) and tumor-bearing mice were treated with various formulations of etoposide, including etoposide entrapped camel milk phospholipids liposomes (ETP-Cam-liposomes) and etoposide-loaded DPPC-liposomes (ETP-DPPC-liposomes). The tumor-bearing mice treated with ETP-Cam-liposomes showed slow progression of tumors and increased survival compared to free ETP or ETP-DPPC-liposomes. These results suggest that ETP-Cam-liposomes may prove to be a better drug delivery system for anticancer drugs.

摘要

从骆驼奶中分离出磷脂，并通过高效液相色谱和气相色谱-质谱联用（GC/MS）进行鉴定。将抗癌药物依托泊苷（ETP）包裹于由骆驼奶磷脂制备的脂质体中，以确定其在小鼠模型中对纤维肉瘤的活性。通过注射苯并芘（BAP）在小鼠体内诱导纤维肉瘤，用多种依托泊苷制剂对荷瘤小鼠进行治疗，包括包裹于骆驼奶磷脂脂质体中的依托泊苷（ETP-骆驼奶脂质体）和负载于二棕榈酰磷脂酰胆碱（DPPC）脂质体中的依托泊苷（ETP-DPPC脂质体）。与游离依托泊苷或ETP-DPPC脂质体相比，用ETP-骆驼奶脂质体治疗的荷瘤小鼠肿瘤进展缓慢且生存期延长。这些结果表明，ETP-骆驼奶脂质体可能是一种更好的抗癌药物递送系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58eb/4363510/374bf4056d5f/BMRI2015-743051.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58eb/4363510/7a0ed62988b9/BMRI2015-743051.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58eb/4363510/68efe6127edd/BMRI2015-743051.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58eb/4363510/06291c59fe02/BMRI2015-743051.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58eb/4363510/54e3305d3404/BMRI2015-743051.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58eb/4363510/be8a5aa76a39/BMRI2015-743051.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58eb/4363510/8ce68c274da5/BMRI2015-743051.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58eb/4363510/374bf4056d5f/BMRI2015-743051.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58eb/4363510/7a0ed62988b9/BMRI2015-743051.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58eb/4363510/68efe6127edd/BMRI2015-743051.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58eb/4363510/06291c59fe02/BMRI2015-743051.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58eb/4363510/54e3305d3404/BMRI2015-743051.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58eb/4363510/be8a5aa76a39/BMRI2015-743051.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58eb/4363510/8ce68c274da5/BMRI2015-743051.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58eb/4363510/374bf4056d5f/BMRI2015-743051.007.jpg

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