Muir B R
Measurement Science and Standards, National Research Council of Canada, 1200 Montreal Road, Ottawa, Ontario K1A 0R6, Canada.
Med Phys. 2015 Apr;42(4):1546-54. doi: 10.1118/1.4914381.
To analyze absorbed dose calibration coefficients, ND,w, measured at accredited dosimetry calibration laboratories (ADCLs) for client ionization chambers to study (i) variability among ND,w coefficients for chambers of the same type calibrated at each ADCL to investigate ion chamber volume fluctuations and chamber manufacturing tolerances; (ii) equivalency of ion chamber calibration coefficients measured at different ADCLs by intercomparing ND,w coefficients for chambers of the same type; and (iii) the long-term stability of ND,w coefficients for different chamber types by investigating repeated chamber calibrations.
Large samples of ND,w coefficients for several chamber types measured over the time period between 1998 and 2014 were obtained from the three ADCLs operating in the United States. These are analyzed using various graphical and numerical statistical tests for the four chamber types with the largest samples of calibration coefficients to investigate (i) and (ii) above. Ratios of calibration coefficients for the same chamber, typically obtained two years apart, are calculated to investigate (iii) above and chambers with standard deviations of old/new ratios less than 0.3% meet stability requirements for accurate reference dosimetry recommended in dosimetry protocols.
It is found that ND,w coefficients for a given chamber type compared among different ADCLs may arise from differing probability distributions potentially due to slight differences in calibration procedures and/or the transfer of the primary standard. However, average ND,w coefficients from different ADCLs for given chamber types are very close with percent differences generally less than 0.2% for Farmer-type chambers and are well within reported uncertainties.
The close agreement among calibrations performed at different ADCLs reaffirms the Calibration Laboratory Accreditation Subcommittee process of ensuring ADCL conformance with National Institute of Standards and Technology standards. This study shows that ND,w coefficients measured at different ADCLs are statistically equivalent, especially considering reasonable uncertainties. This analysis of ND,w coefficients also allows identification of chamber types that can be considered stable enough for accurate reference dosimetry.
分析在认可的剂量校准实验室(ADCLs)为客户电离室测量的吸收剂量校准系数ND,w,以研究:(i)在每个ADCL校准的同一类型电离室的ND,w系数之间的变异性,以调查电离室体积波动和电离室制造公差;(ii)通过比较同一类型电离室的ND,w系数,研究在不同ADCL测量的电离室校准系数的等效性;以及(iii)通过调查电离室的重复校准,研究不同类型电离室的ND,w系数的长期稳定性。
从在美国运营的三个ADCL获得了1998年至2014年期间测量的几种电离室类型的大量ND,w系数样本。使用各种图形和数值统计测试对校准系数样本量最大的四种电离室类型进行分析,以研究上述(i)和(ii)。计算通常相隔两年获得的同一电离室校准系数的比率,以研究上述(iii),并且旧/新比率标准偏差小于0.3%的电离室符合剂量测定协议中推荐的准确参考剂量测定的稳定性要求。
发现在不同ADCL之间比较的给定电离室类型的ND,w系数可能源于不同的概率分布,这可能是由于校准程序的细微差异和/或初级标准的传递。然而,对于给定电离室类型,不同ADCL的平均ND,w系数非常接近,对于 Farmer 型电离室,百分比差异通常小于0.2%,并且完全在报告的不确定度范围内。
在不同ADCL进行的校准之间的密切一致性再次确认了校准实验室认可小组委员会确保ADCL符合美国国家标准与技术研究院标准的过程。本研究表明,在不同ADCL测量的ND,w系数在统计上是等效的,特别是考虑到合理的不确定度。对ND,w系数的这种分析还允许识别对于准确参考剂量测定足够稳定的电离室类型。