Claflin Kristin E, Grobe Justin L
Department of Pharmacology, Center for Hypertension Research, Obesity Research & Education Initiative, François M. Abboud Cardiovascular Research Center, and Fraternal Order of Eagles' Diabetes Research Center, University of Iowa, 51 Newton Rd., 2-307 BSB, Iowa City, IA, 52242, USA.
Curr Hypertens Rep. 2015 May;17(5):38. doi: 10.1007/s11906-015-0549-x.
The renin-angiotensin system (RAS) exists as a circulating hormone system but it is also used by various tissues of the body, including the brain, as a paracrine signaling mechanism. The local brain version of the RAS is mechanistically involved in fluid balance and blood pressure control, and there is growing appreciation for a role of the brain RAS in the control of energy balance. Here, we review major evidence for the control of energy balance by the brain RAS; outline the current understanding of the RAS components, targets, and mechanisms involved; and highlight some major questions that currently face the field.
肾素-血管紧张素系统（RAS）作为一种循环激素系统存在，但它也被身体的各种组织（包括大脑）用作旁分泌信号机制。大脑局部的RAS在机制上参与了体液平衡和血压控制，并且人们越来越认识到大脑RAS在能量平衡控制中的作用。在这里，我们回顾了大脑RAS控制能量平衡的主要证据；概述了目前对RAS的组成部分、靶点和相关机制的理解；并强调了该领域目前面临的一些主要问题。
