纳米羟基磷灰石、硝酸钾、单氟磷酸钠和抗氧化剂对牙齿过敏的缓解作用
Reduction in dental hypersensitivity with nano-hydroxyapatite, potassium nitrate, sodium monoflurophosphate and antioxidants.
作者信息
B Low Samuel, Allen Edward P, Kontogiorgos Elias D
机构信息
Department of Periodontics, University of Florida College of Dentistry, University of Florida, Gainesville, Florida 32610, USA; ; Department of Restorative Sciences, Texas A&M, Baylor University, College of Dentistry, Dallas, Texas 75246, USA;
Department of Periodontics, Texas A&M University, Baylor College of Dentistry; Dallas, Texas 75246, USA;
出版信息
Open Dent J. 2015 Feb 27(9):92-7. doi: 10.2174/1874364101509010092. eCollection 2015.
OBJECTIVE
This clinical study aimed to evaluate effectiveness of a commercially available toothpaste containing potassium nitrate, sodium monoflurophosphate, and nano-hydroxyapatite as well as antioxidants phloretin, ferulic acid and silymarin in reducing dental hypersensitivity in adults.
METHODS
The clinical trial enrolled patients with a history of dentin hypersensitivity. A test toothpaste was introduced into the daily routine, which included initial instruction on usage. Patients completed a five-question visual analog scale (VAS) at the inception/baseline, after two days and after two weeks of using the toothpaste to determine their level of tooth sensitivity at baseline with the use of the toothpaste over time.
RESULTS
Patients that had significant sensitivity at baseline had a range of 52% to 76 % improvement after 48 hours and a range of 70% to 84% improvement after two weeks.
CONCLUSION
A toothpaste containing potassium nitrate, sodium monoflurophosphate, and nano-hydroxyapatite plus antioxidants phloretin, ferulic acid and silymarin applied daily significantly decreased tooth pain of dentin hypersensitivity within a two-day and two-week time period.
CLINICAL SIGNIFICANCE
Based on the clinical study results, a daily application of a toothpaste containing potassium nitrate, sodium monofluorophosphate, and nano-hydroxyapatite plus antioxidants phloretin, ferulic acid and silymarin can significantly and quickly reduce tooth pain of dentin hypersensitivity.
目的
本临床研究旨在评估一种市售牙膏的有效性，该牙膏含有硝酸钾、单氟磷酸钠、纳米羟基磷灰石以及抗氧化剂根皮素、阿魏酸和水飞蓟宾，用于减轻成人牙齿敏感。
方法
该临床试验招募有牙本质过敏史的患者。将一种试验牙膏引入日常使用，包括最初的使用指导。患者在开始/基线时、使用牙膏两天后和两周后完成一份包含五个问题的视觉模拟量表（VAS），以确定随着时间推移使用该牙膏时他们在基线时的牙齿敏感程度。
结果
在基线时具有显著敏感性的患者在48小时后改善范围为52%至76%，在两周后改善范围为70%至84%。
结论
一种含有硝酸钾、单氟磷酸钠、纳米羟基磷灰石以及抗氧化剂根皮素、阿魏酸和水飞蓟宾的牙膏每日使用，在两天和两周的时间段内可显著减轻牙本质过敏的牙痛。
临床意义
基于临床研究结果，每日使用一种含有硝酸钾、单氟磷酸钠、纳米羟基磷灰石以及抗氧化剂根皮素、阿魏酸和水飞蓟宾的牙膏可显著且快速地减轻牙本质过敏的牙痛。
Zotero 插件