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鼓室硬化症患者颈动脉内膜中层厚度增加:与动脉粥样硬化有共同的危险因素吗?

Increased carotid artery intima-media thickness in patients with tympanosclerosis: Common risk factors with atherosclerosis?

作者信息

Doluoglu Sumeyra, Gocer Celil, Toprak Ugur, Iriz Ayse, Uyar Melek, Eryilmaz Adil

机构信息

Department of ENT, III Clinic of Ankara Numune Education and Research Hospital, Ankara, Turkey.

Department of ENT, III Clinic of Ankara Numune Education and Research Hospital, Ankara, Turkey.

出版信息

Kaohsiung J Med Sci. 2015 Apr;31(4):199-202. doi: 10.1016/j.kjms.2015.01.003. Epub 2015 Feb 9.

Abstract

We investigated the relationship between tympanosclerosis, known atherosclerotic risk factors, and the intima-media thickness of bilateral carotid arteries using ultrasonography. A total of 122 patients admitted to our clinic with chronic otitis media between 2005 and 2010 were included in the study. The study group consisted of 61 patients with tympanosclerosis; the control group comprised 61 patients without tympanosclerosis. Internal carotid artery intima-media thickness (CAIMT), total cholesterol, triglyceride, low- and high-density lipoprotein cholesterol, C-reactive protein, and homocysteine levels were measured in all patients. Homocysteine, low-density lipoprotein, total cholesterol, and triglyceride levels in the study group were higher compared with those of the control group (p < 0.05). Right and left CAIMT was greater in the study group versus the control group (p ≤ 0.001). In conclusion, atherosclerosis and tympanosclerosis were associated with identical risk factors; in the tympanosclerosis group, CAIMT was increased significantly.

摘要

我们使用超声检查研究了鼓室硬化症、已知的动脉粥样硬化风险因素与双侧颈动脉内膜中层厚度之间的关系。2005年至2010年间因慢性中耳炎入住我院门诊的122例患者纳入本研究。研究组由61例鼓室硬化症患者组成;对照组由61例无鼓室硬化症的患者组成。测量了所有患者的颈内动脉内膜中层厚度(CAIMT)、总胆固醇、甘油三酯、低密度和高密度脂蛋白胆固醇、C反应蛋白及同型半胱氨酸水平。研究组的同型半胱氨酸、低密度脂蛋白、总胆固醇及甘油三酯水平高于对照组(p < 0.05)。研究组的左右CAIMT均大于对照组(p≤0.001)。总之,动脉粥样硬化与鼓室硬化症存在相同的风险因素;在鼓室硬化症组中,CAIMT显著增加。

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Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis?
J Laryngol Otol. 2011 Nov;125(11):1121-4. doi: 10.1017/S0022215111002301. Epub 2011 Sep 5.
8
Sex distribution in children with tympanosclerosis after insertion of a tympanostomy tube.
Eur Arch Otorhinolaryngol. 2001 Jan;258(1):16-9. doi: 10.1007/pl00007517.
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The role of oxidized lipoproteins in atherogenesis.氧化脂蛋白在动脉粥样硬化形成中的作用。
Free Radic Biol Med. 1996;20(5):707-27. doi: 10.1016/0891-5849(95)02173-6.

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