Bleasel A F, Waugh R C, McCaughan G W
Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia.
Gut. 1989 Oct;30(10):1419-23. doi: 10.1136/gut.30.10.1419.
It is well known that chronic encephalopathy may be a major complication after the establishment of a surgical portal caval shunt for an episode of variceal haemorrhage. In an effort to minimise this problem Warren and colleagues developed the distal splenorenal shunt where the portal and mesenteric blood flow to the liver was left intact. It is now recognised, however, that the longterm incidence of encephalopathy may be no different with this type of shunt compared with conventional surgical portal systemic shunts. Acquired chronic hepatocerebral degeneration has not been reported after such a selective shunt. A patient with primary biliary cirrhosis is reported who developed the clinical features of this syndrome eight years after a successful distal splenorenal shunt.
众所周知,慢性脑病可能是为治疗静脉曲张出血而进行外科门腔分流术后的主要并发症。为尽量减少这一问题,沃伦及其同事研发了远端脾肾分流术,该术式可使门静脉和肠系膜血流完整地流入肝脏。然而,目前人们认识到,与传统外科门体分流术相比,这种分流术的脑病长期发生率可能并无差异。在这种选择性分流术后,尚未有获得性慢性肝脑变性的报道。本文报告了一名原发性胆汁性肝硬化患者,该患者在成功进行远端脾肾分流术后八年出现了该综合征的临床特征。