Department of Pharmacology and Catholic Neuroscience Institute, School of Medicine, the Catholic University of Korea, Seoul 137-701, South Korea.
Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Cell Stem Cell. 2015 Apr 2;16(4):344-5. doi: 10.1016/j.stem.2015.03.015.
Long noncoding RNAs (lncRNAs) influence diverse cellular processes and have been implicated in regulating stem cell properties. Now in Cell Stem Cell, Ramos et al. (2015) demonstrate that the neural-specific lncRNA Pnky regulates neuronal differentiation from neural stem cells and mediates RNA splicing through interactions with polypyrimidine tract-binding protein 1 (PTBP1).
长非编码 RNA（lncRNAs）影响多种细胞过程，并被认为在调节干细胞特性中起作用。现在，Ramos 等人在《Cell Stem Cell》杂志上（2015）表明，神经特异性 lncRNA Pnky 调节神经干细胞向神经元的分化，并通过与多嘧啶 tract 结合蛋白 1（PTBP1）相互作用来介导 RNA 剪接。
