Sydlik Stefanie A, Jhunjhunwala Siddharth, Webber Matthew J, Anderson Daniel G, Langer Robert
∥Department of Anesthesiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
ACS Nano. 2015;9(4):3866-74. doi: 10.1021/acsnano.5b01290. Epub 2015 Apr 10.
Graphene oxide (GO) is suggested to have great potential as a component of biomedical devices. Although this nanomaterial has been demonstrated to be cytocompatible in vitro, its compatibility in vivo in tissue sites relevant for biomedical device application is yet to be fully understood. Here, we evaluate the compatibility of GO with two different oxidation levels following implantation in subcutaneous and intraperitoneal tissue sites, which are of broad relevance for application to medical devices. We demonstrate GO to be moderately compatible in vivo in both tissue sites, with the inflammatory reaction in response to implantation consistent with a typical foreign body reaction. A reduction in the degree of GO oxidation results in faster immune cell infiltration, uptake, and clearance following both subcutaneous and peritoneal implantation. Future work toward surface modification or coating strategies could be useful to reduce the inflammatory response and improve compatibility of GO as a component of medical devices.
氧化石墨烯（GO）被认为作为生物医学设备的一个组件具有巨大潜力。尽管这种纳米材料已在体外被证明具有细胞相容性，但其在与生物医学设备应用相关的组织部位的体内相容性尚未得到充分了解。在这里，我们评估了两种不同氧化水平的GO在皮下和腹腔组织部位植入后的相容性，这两个部位与医疗设备的应用密切相关。我们证明GO在这两个组织部位的体内相容性中等，植入后的炎症反应与典型的异物反应一致。GO氧化程度的降低导致皮下和腹腔植入后免疫细胞浸润、摄取和清除速度加快。未来针对表面改性或涂层策略的研究可能有助于减少炎症反应并提高GO作为医疗设备组件的相容性。
