Jabbarvand M, Hashemian H, Khodaparast M, Bazvand F, Beheshtnejad A
Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Eye (Lond). 2015 Jun;29(6):783-90. doi: 10.1038/eye.2015.33. Epub 2015 Mar 27.
To evaluate the effect of complete intrastromal corneal ring implantations on patients with pellucid marginal degeneration (PMD).
Prospective interventional case series.
Thirty-three eyes with PMD were included into the study. After pocket creation with femtosecond laser (Femtec; 20/10 PerfectVision), MyoRing implantation was performed. Uncorrected and corrected distance visual acuity (UDVA, CDVA), subjective refraction, keratometry, central corneal thickness, corneal biomechanical profile (Ocular Response Analysis), and whole-eye wavefront aberrometry (iTrace) were evaluated preoperatively and also postoperatively, 1 month, 3 months, 6 months, and 1 year after the operation.
One month after surgery, significant improvements were observed in UDVA (ANOVA; P=0.02), mean keratometry, sphere (ANOVA; P <0.001), and cylinder (ANOVA; P=0.04) with no significant changes afterwards. No significant change occurred in the corneal biomechanical profile. Primary coma and trefoil reduced after 1 year (ANOVA; P values were 0.02 and 0.06, respectively). Primary spherical aberration significantly increased according to the 1-year follow-up (ANOVA; P<0.001). No significant complication was observed.
MyoRing is considered as a treatment modality for spherocylindrical correction in patients with PMD, with an acceptable safety and efficacy profile.
评估全层角膜基质环植入术对透明边缘变性（PMD）患者的疗效。
前瞻性干预性病例系列研究。
33只患有PMD的眼睛被纳入研究。使用飞秒激光（Femtec；20/10 PerfectVision）制作植床后，植入MyoRing。在术前以及术后1个月、3个月、6个月和1年时评估未矫正和矫正远视力（UDVA、CDVA）、主观验光、角膜曲率测量、中央角膜厚度、角膜生物力学特征（眼反应分析仪）和全眼波前像差测量（iTrace）。
术后1个月，UDVA（方差分析；P = 0.02）、平均角膜曲率、球镜（方差分析；P <0.001）和柱镜（方差分析；P = 0.04）有显著改善，之后无显著变化。角膜生物力学特征无显著变化。1年后初级彗差和三叶草像差降低（方差分析；P值分别为0.02和0.06）。根据1年随访，初级球差显著增加（方差分析；P <0.001）。未观察到显著并发症。
MyoRing被认为是治疗PMD患者球柱镜矫正的一种治疗方式，具有可接受的安全性和疗效。
