Yang Da-Song, Wang Shuang-Mei, Peng Wei-Bing, Yang Yong-Ping, Liu Ke-Chun, Li Xiao-Li, Xiao Wei-Lie
Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.
Biology Institute of Shandong Academy of Sciences, Jinan, 250014 People's Republic of China.
Nat Prod Bioprospect. 2015 Apr 10;5(2):105-109. doi: 10.1007/s13659-015-0059-1. eCollection 2015 Apr.
Three new minor prenylated flavonoids, named macadenanthins A-C (-), together with three known ones (-), were isolated from the twigs of . Their structures were elucidated on the basis of extensive spectroscopic analysis including NMR, UV and MS. The prenyl moieties in compounds - were further modified by cyclization and hydroxylation. The new compounds were tested for their cytotoxicity against four cancer cell lines (MCF-7, Hep G2, Hela and P388) and showed IC values in the range of 13.76-22.27 μM.
从……的嫩枝中分离出三种新的次要异戊烯基化黄酮类化合物，命名为澳洲坚果黄素A - C（-），以及三种已知的（-）。它们的结构通过包括核磁共振（NMR）、紫外（UV）和质谱（MS）在内的广泛光谱分析得以阐明。化合物……中的异戊烯基部分通过环化和羟基化进一步修饰。测试了这些新化合物对四种癌细胞系（MCF - 7、Hep G2、Hela和P388）的细胞毒性，其半数抑制浓度（IC）值在13.76 - 22.27μM范围内。
