Suryadeva Sreevalli, Khan Mohammadi Begum
Associate Professor, Department of Orthodontics, Drs. Sudha and Nageswara Rao Pinnamineni Siddhartha Institute of Dental Sciences , Gunnavaram, Vijayawada, Andhara Pradesh, India .
Assistant Professor, Department of Orthodontics, Drs. Sudha and Nageswara Rao Pinnamineni Siddhartha Institute of Dental Sciences , Gunnavaram, Vijayawada, Andhara Pradesh, India .
J Clin Diagn Res. 2015 Feb;9(2):ZE09-12. doi: 10.7860/JCDR/2015/11067.5606. Epub 2015 Feb 1.
In oral cavity, disturbances due to genetic alterations may range from lack of tooth development to morphological defects. Due to technical advances in genetic engineering and molecular biology, valuable information regarding dentofacial growth could be studied in detailed manner. This helped us to explain the aetiology and pathogenesis of many dentofacial disorders. The success in treatment lies first in determining the aetiology of tooth anomalies and finally differentiating the effect of genes and environment on the orofacial diseases of that particular individual. Several genes belonging to class II homeobox families are expressed during odontogenesis however homeobox genes are not directly imvolved in tooth formation as they are not directly expressed in the first branchial arch derivatives.
在口腔中，基因改变引起的紊乱可能从牙齿发育不全到形态缺陷不等。由于基因工程和分子生物学的技术进步，可以详细研究有关牙颌面生长的宝贵信息。这有助于我们解释许多牙颌面疾病的病因和发病机制。治疗的成功首先在于确定牙齿异常的病因，最终区分基因和环境对该特定个体口腔疾病的影响。属于II类同源框家族的几个基因在牙胚发生过程中表达，然而同源框基因并不直接参与牙齿形成，因为它们不在第一鳃弓衍生物中直接表达。
