基于原子力显微镜的力追踪记录单个金纳米颗粒的动态内吞作用。
Recording the dynamic endocytosis of single gold nanoparticles by AFM-based force tracing.
机构信息
School of Physics, Northeast Normal University, Changchun, Jilin 130024, P.R. China.
出版信息
Nanoscale. 2015 May 7;7(17):7545-9. doi: 10.1039/c5nr01020a.
PMID:25864702
Abstract
We utilized force tracing to directly record the endocytosis of single gold nanoparticles (Au NPs) with different sizes, revealing the size-dependent endocytosis dynamics and the crucial role of membrane cholesterol. The force, duration and velocity of Au NP invagination are accurately determined at the single-particle and microsecond level unprecedentedly.
摘要
我们利用力追踪技术直接记录了不同尺寸的单个金纳米粒子（Au NPs）的内吞作用，揭示了尺寸依赖性的内吞动力学以及膜胆固醇的关键作用。在单颗粒和微秒水平上，前所未有地精确确定了 Au NP 内陷的力、持续时间和速度。
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