Kim Eunjeong, Park HyeSook, Hong Yun-Chul, Ha Mina, Kim Yangho, Lee Bo-Eun, Ha Eun-Hee
Department of Preventive Medicine, Ewha Medical Research Center, Ewha Womans University, Seoul, South Korea.
Department of Preventive Medicine, College of Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Ann Occup Environ Med. 2015 Mar 20;27:8. doi: 10.1186/s40557-015-0059-y. eCollection 2015.
Limited evidence is available regarding the association between prenatal job strain and infant neurodevelopment. Most studies used stress indicators other than job strain to explain the relationship between prenatal maternal stress and child development. The objective of this study was to investigate the association between maternal job strain during pregnancy and neurodevelopment in infancy.
Mothers and Children's Environmental Health (MOCEH) study, an on-going prospective birth cohort study, has been conducted in South Korea since 2006. Job strain during pregnancy was measured using Korean version of Job Content Questionnaire (JCQ). Infant neurodevelopment was assessed using Korean Bayley Scale of Infant Development II (K-BSID-II) at 6 and 12 months of age. A total of 343 mother-child pairs that completed JCQ and K-BSID-II more than once were included. Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI) defined in the K-BSID-II were used as outcome variables.
Compared to infants from mothers with low job strain, significant (p < 0.05) decreases in PDI were found in infants from mothers with active and passive job at 6 months of age. After stratification by infant sex, boys in the high strain group had a lower MDI score than boys in the low job strain group at 12 months. On the other hand, girls in the high strain and active groups had higher MDI scores than girls in the low job strain group at 12 months. PDI at 12 months also showed different results by sex. Boys in the high strain and passive job groups had lower PDI scores than boys in the low job strain group. However, such difference was not observed in girls.
The findings of this study suggest that prenatal job strain affects infant neurodevelopment in a gender-dependent manner.
关于产前工作压力与婴儿神经发育之间的关联，现有证据有限。大多数研究使用工作压力以外的压力指标来解释产前母亲压力与儿童发育之间的关系。本研究的目的是调查孕期母亲工作压力与婴儿期神经发育之间的关联。
母婴环境健康（MOCEH）研究是一项正在进行的前瞻性出生队列研究，自2006年起在韩国开展。使用韩国版工作内容问卷（JCQ）测量孕期工作压力。在婴儿6个月和12个月大时，使用韩国贝利婴儿发展量表第二版（K-BSID-II）评估婴儿神经发育。共纳入343对多次完成JCQ和K-BSID-II的母婴对。将K-BSID-II中定义的心理发展指数（MDI）和心理运动发展指数（PDI）用作结局变量。
与工作压力低的母亲所生婴儿相比，6个月大时，主动和被动工作母亲所生婴儿的PDI显著降低（p<0.05）。按婴儿性别分层后，高压力组男孩在12个月时的MDI得分低于低工作压力组男孩。另一方面，12个月时，高压力组和主动组女孩的MDI得分高于低工作压力组女孩。12个月时的PDI也因性别呈现不同结果。高压力和被动工作组男孩的PDI得分低于低工作压力组男孩。然而，女孩中未观察到这种差异。
本研究结果表明，产前工作压力以性别依赖的方式影响婴儿神经发育。
