Wehner Frank, Mußhoff Frank, Schulz Martin M, Martin David D, Wehner Heinz-Dieter
Institute for Legal Medicine Tübingen, Nägelestraße 5, D-72074, Tübingen, Germany,
Forensic Sci Med Pathol. 2006 Sep;2(3):193-7. doi: 10.1007/s12024-006-0009-7.
The accidental ingestion of plant material containing colchicines is a rare cause of lethal poisoning. The death of a married couple who mistook colchicines for Bear's garlic (Allium ursinum) and prepared the latter as a salad is the tragic topic of this article. After discussing the specificity of the histological findings, a chemicotoxicological method using liquid chromatographic mass spectrometric (LC-MS/MS) is presented. Toxicological analyses using LC-MS/MS revealed colchicine concentrations between 36.6 ng/mL and 98.3 ng/mL in the heart blood and between 22.7 ng/mL and 78.4 ng/mL in the femoral blood of the victims.
意外摄入含有秋水仙碱的植物材料是致死性中毒的罕见原因。一对夫妻误将秋水仙碱当作熊葱（熊蒜）并将其做成沙拉食用，最终死亡，这对夫妻的死亡是本文的悲剧主题。在讨论了组织学发现的特异性之后，本文介绍了一种使用液相色谱质谱联用仪（LC-MS/MS）的化学毒理学方法。使用LC-MS/MS进行的毒理学分析显示，受害者心血中秋水仙碱浓度在36.6纳克/毫升至98.3纳克/毫升之间，股血中秋水仙碱浓度在22.7纳克/毫升至78.4纳克/毫升之间。
