Sundov Zeljko, Nincevic Zeljko, Definis-Gojanovic Marija, Glavina-Durdov Merica, Jukic Ivana, Hulina Nada, Tonkic Ante
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Clinical Hospital Split, Spinciceva 1, 21000 Split, Croatia.
Forensic Sci Int. 2005 May 10;149(2-3):253-6. doi: 10.1016/j.forsciint.2004.06.034.
A 62-year-old male died of colchicine poisoning after accidental ingestion of Colchicum autumnale (meadow saffron). He ate a salad of plant with green leaves regarded as wild garlic (Allium ursinum). A few hours later he developed symptoms of gastroenteritis and was admitted to hospital. In spite of gastric lavage, activated charcoal and supportive measures, multi-organ system failure developed over the next two days. Laboratory analysis showed highly elevated blood concentrations of hepatic enzymes, creatine kinase, lactate dehydrogenase and blood urea nitrogen, as well as leukocytopenia and thrombocytopenia. Mechanical ventilation, dopamine, noradrenaline, crystalloid solutions and fresh frozen plasma were applied but despite treatment the patient died five days after the ingestion. Post-mortem examination revealed hepatic centrilobular necrosis, nephrotoxic acute tubular necrosis, petechial bleeding in fatty tissue, blunt and shortened intestinal villi and cerebral toxic edema. Botanical identification of incriminated plant gave Colchicum autumnale which confirmed colchicine poisoning. Although the accidental ingestion of Colchicum autumnale is rare and to our knowledge only five such cases have been described in detail, this is the second fatal case in Croatia described in the last 3 years.
一名62岁男性因误食秋水仙（草地藏红花）导致秋水仙碱中毒死亡。他食用了一种被认为是野生大蒜（熊葱）的绿叶植物沙拉。数小时后，他出现了肠胃炎症状并入院治疗。尽管进行了洗胃、给予活性炭及采取了支持措施，但在接下来的两天里，多器官系统功能衰竭仍不断发展。实验室分析显示，血液中肝酶、肌酸激酶、乳酸脱氢酶和血尿素氮浓度大幅升高，同时伴有白细胞减少和血小板减少。患者接受了机械通气、多巴胺、去甲肾上腺素、晶体溶液和新鲜冰冻血浆治疗，但尽管如此，患者在摄入植物五天后仍死亡。尸检显示肝小叶中心坏死、肾毒性急性肾小管坏死、脂肪组织点状出血、肠绒毛变钝和缩短以及脑中毒性水肿。对涉案植物进行植物学鉴定，确定为秋水仙，证实为秋水仙碱中毒。尽管误食秋水仙的情况罕见，据我们所知仅有五例详细报道，但这是克罗地亚过去三年中描述的第二例致命病例。
