Department of Surgery, Sahlgrenska University Hospital and Sahlgrenska Academy, University of Gothenberg, 41345 Gothenburg, Sweden.
Paediatric Surgical Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Nat Rev Clin Oncol. 2015 Jul;12(7):425-31. doi: 10.1038/nrclinonc.2015.72. Epub 2015 Apr 14.
Patients with cancer generally have better outcomes when treated as part of a clinical trial compared with patients not enrolled in a clinical trial. Unfortunately, surgical participation in, and leadership of such studies, is limited. This lack of clinical investigation is adversely affecting progress in cancer surgery research and, ultimately, hinders the treatment of patients. Some of the reasons for poor surgical participation in clinical research include: limitations on funding provision; inadequate training of junior surgeons in clinical trials methodology; and inadequate support of surgical faculty members as clinical investigators. Despite these shortcomings, numerous successful surgical studies have helped to change concepts, and improve patient care in certain clinical areas. Finally, a number of possible solutions are proposed, which might improve surgical involvement in clinical trials and result in more, and better-designed and executed clinical trials in this important area of research.
与未参加临床试验的患者相比，作为临床试验的一部分接受治疗的癌症患者通常会有更好的结果。不幸的是，外科手术参与此类研究的程度和领导力有限。这种缺乏临床研究的情况正在阻碍癌症外科手术研究的进展，最终影响患者的治疗。外科手术在临床研究中参与度低的部分原因包括：资金提供的限制；对初级外科医生进行临床试验方法学培训不足；以及对外科教员作为临床研究人员的支持不足。尽管存在这些缺点，但许多成功的外科研究帮助改变了观念，并在某些临床领域改善了患者的护理。最后，提出了一些可能的解决方案，这些方案可能会提高外科手术在临床试验中的参与度，并在这一重要研究领域产生更多、设计和执行更好的临床试验。
