富含多酚的葡萄皮渣提取物可预防葡聚糖硫酸钠诱导的大鼠结肠炎。
Polyphenol-rich grape pomace extracts protect against dextran sulfate sodium-induced colitis in rats.
作者信息
Boussenna Ahlem, Cholet Juliette, Goncalves-Mendes Nicolas, Joubert-Zakeyh Juliette, Fraisse Didier, Vasson Marie-Paule, Texier Odile, Felgines Catherine
机构信息
Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, Equipe ECREIN, Laboratoire de Pharmacognosie et Phytothérapie, 28 Place Henri-Dunant, F-63000, Clermont-Ferrand, France.
3inature Biosphère, Parc Naturopôle Les Tiolans, F-03800, Saint-Bonnet-de-Rochefort, France.
出版信息
J Sci Food Agric. 2016 Mar 15;96(4):1260-8. doi: 10.1002/jsfa.7214. Epub 2015 May 8.
BACKGROUND
Several studies have reported that polyphenols may exert beneficial effects on inflammatory bowel disease. This study aimed to evaluate the effects of preventive consumption of polyphenol-rich red grape pomace extracts (GPEs) on dextran sulfate sodium (DSS)-induced colitis in rats. Rats were fed for 21 days with a semi-synthetic diet enriched with a GPE (Alicante-S, Alicante-P or Pinot-S) and colitis was induced by DSS administration in drinking water (40 g L(-1) ) during the last 7 days of experimentation.
RESULTS
GPEs attenuated clinical signs and colon shortening and Alicante GPEs limited histological lesions induced by DSS. GPEs curbed the increase in myeloperoxidase activity and modulated antioxidant enzyme activities. Moreover, GPEs prevented the DSS-induced increase in pro-inflammatory cytokine levels and the up-regulation of various genes implicated in colitis such as intercellular adhesion molecule 1 (ICAM-1) and matrix metalloproteinase 9 (MMP-9).
CONCLUSION
These results suggest that polyphenol-rich red GPEs could provide prevention against colon inflammation.
背景
多项研究报告称，多酚可能对炎症性肠病产生有益影响。本研究旨在评估预防性食用富含多酚的红葡萄渣提取物（GPEs）对葡聚糖硫酸钠（DSS）诱导的大鼠结肠炎的影响。给大鼠喂食富含GPE（阿利坎特-S、阿利坎特-P或黑皮诺-S）的半合成饮食21天，并在实验的最后7天通过在饮用水中给予DSS（40 g L⁻¹）诱导结肠炎。
结果
GPEs减轻了临床症状和结肠缩短，阿利坎特GPEs限制了DSS诱导的组织学损伤。GPEs抑制了髓过氧化物酶活性的增加并调节了抗氧化酶活性。此外，GPEs预防了DSS诱导的促炎细胞因子水平升高以及与结肠炎相关的各种基因如细胞间粘附分子1（ICAM-1）和基质金属蛋白酶9（MMP-9）的上调。
结论
这些结果表明，富含多酚的红色GPEs可以预防结肠炎症。
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