Kitagawa K, Nishida S, Ogura Y
Department of Ophthalmology, Aichi Medical University, Japan.
Ophthalmologica. 1989;199(2-3):116-21. doi: 10.1159/000310027.
We measured autofluorescence of the macula with fluorophotometry to evaluate age-related changes in human retinal pigment epithelium. Examined in this study were 35 aphakic eyes of 25 patients, ranging in age from 52 to 87 years, after uneventful intracapsular cataract extraction and 21 normal phakic eyes of 20 patients, ranging in age from 9 to 29 years. Autofluorescence at the macula of aphakic eyes increased in an age-dependent manner (r = 0.514; p less than 0.01) as follows: 15.0 ngEq/ml for the sixth decade (n = 1), 17.2 +/- 4.2 for the seventh decade (n = 11), 21.3 +/- 3.6 for the eighth decade (n = 16) and 24.6 +/- 2.7 for the ninth decade (n = 7). We believe that the autofluorescence originates mainly from lipofuscin in the retinal pigment epithelium, and that the autofluorescence enhanced with age reflects the accumulation of lipofuscin.
我们用荧光光度法测量黄斑区的自发荧光，以评估人类视网膜色素上皮的年龄相关变化。本研究检查了25例年龄在52至87岁之间的患者的35只无晶状体眼，这些患者均接受了顺利的囊内白内障摘除术，以及20例年龄在9至29岁之间的患者的21只正常有晶状体眼。无晶状体眼黄斑区的自发荧光呈年龄依赖性增加（r = 0.514；p < 0.01），具体如下：第六个十年为15.0 ngEq/ml（n = 1），第七个十年为17.2±4.2（n = 11），第八个十年为21.3±3.6（n = 16），第九个十年为24.6±2.7（n = 7）。我们认为自发荧光主要来源于视网膜色素上皮中的脂褐素，且随着年龄增长而增强的自发荧光反映了脂褐素的积累。
