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孕妇对百日咳围产期策略及其他与妊娠相关的推荐免疫接种的接受情况。

Maternal uptake of pertussis cocooning strategy and other pregnancy related recommended immunizations.

作者信息

Wong C Y, Thomas N J, Clarke M, Boros C, Tuckerman J, Marshall H S

机构信息

a Vaccinology and Immunology Research Trials Unit; Women's and Children's Hospital ; North Adelaide , South Australia , Australia.

出版信息

Hum Vaccin Immunother. 2015;11(5):1165-72. doi: 10.1080/21645515.2015.1019188.

Abstract

Maternal immunization is an important strategy to prevent severe morbidity and mortality in mothers and their offspring. This study aimed to identify whether new parents were following immunization recommendations prior to pregnancy, during pregnancy, and postnatally. A cross-sectional survey was conducted by a questionnaire administered antenatally to pregnant women attending a maternity hospital with a follow-up telephone interview at 8-10 weeks post-delivery. Factors associated with uptake of pertussis vaccination within the previous 5 y or postnatally and influenza vaccination during pregnancy were explored using log binomial regression models. A total of 297 pregnant women completed the questionnaire. For influenza vaccine, 20.3% were immunized during pregnancy and 3.0% postnatally. For pertussis vaccine, 13.1% were vaccinated within 5 y prior to pregnancy and 31 women received the vaccine postnatally, 16 (51.6%) received the vaccine >4 weeks after delivery. Receiving a recommendation from a healthcare provider (HCP) was an independent predictor for receipt of both pertussis (RR 2.07, p < 0.001) and influenza vaccine (RR 2.26, p = 0.001). Non-English speaking mothers were significantly less likely to have received pertussis vaccination prior to pregnancy or postnatally (RR 0.24, p = 0.011). Multiparous pregnant women were less likely to have received an influenza vaccine during their current pregnancy (p = 0.015). Uptake of pregnancy related immunization is low and likely due to poor knowledge of availability, language barriers and lack of recommendations from HCPs. Strategies to improve maternal vaccine uptake should include education about recommended vaccines for both HCPs and parents and written information in a variety of languages.

摘要

孕产妇免疫是预防母亲及其后代严重发病和死亡的一项重要策略。本研究旨在确定初为人父母者在怀孕前、怀孕期间及产后是否遵循免疫接种建议。通过在产前对一家妇产医院的孕妇进行问卷调查,并在分娩后8至10周进行电话随访,开展了一项横断面调查。使用对数二项回归模型探讨了与过去5年内或产后百日咳疫苗接种以及孕期流感疫苗接种相关的因素。共有297名孕妇完成了问卷调查。对于流感疫苗,20.3%的孕妇在孕期接种,3.0%在产后接种。对于百日咳疫苗,13.1%在怀孕前5年内接种,31名妇女在产后接种,其中16名(51.6%)在分娩后4周以上接种。接受医疗保健提供者(HCP)的建议是接受百日咳疫苗(相对危险度2.07,p<0.001)和流感疫苗(相对危险度2.26,p = 0.001)接种的独立预测因素。非英语母语的母亲在怀孕前或产后接受百日咳疫苗接种的可能性显著降低(相对危险度0.24,p = 0.011)。经产妇在本次怀孕期间接受流感疫苗接种的可能性较小(p = 0.015)。与怀孕相关的免疫接种率较低,可能是由于对疫苗可及性了解不足、语言障碍以及缺乏医疗保健提供者的建议。提高孕产妇疫苗接种率的策略应包括对医疗保健提供者和父母进行关于推荐疫苗的教育,并提供多种语言的书面信息。

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