Fagan Pebbles, Moolchan Eric T, Pokhrel Pallav, Herzog Thaddeus, Cassel Kevin D, Pagano Ian, Franke Adrian A, Kaholokula Joseph Keawe'aimoku, Sy Angela, Alexander Linda A, Trinidad Dennis R, Sakuma Kari-Lyn, Johnson C Anderson, Antonio Alyssa, Jorgensen Dorothy, Lynch Tania, Kawamoto Crissy, Clanton Mark S
Pebbles Fagan, Pallav Pokhrel, Thaddeus Herzog, Kevin D. Cassel, Ian Pagano, Adrian A. Franke, Alyssa Antonio, Dorothy Jorgensen, Tania Lynch, and Crissy Kawamoto are with the University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu. Eric T. Moolchan is an independent consultant, Cambridge, MA. Joseph Keawe'aimoku Kaholokula is with the John A. Burns School of Medicine, University of Hawaii at Manoa. Angela Sy is with the School of Nursing and Dental Hygiene, University of Hawaii at Manoa. Linda A. Alexander is with the University of Kentucky College of Public Health, Lexington. Dennis R. Trinidad and C. Anderson Johnson are with the School of Community and Global Health, Claremont Graduate University, CA. Kari-Lyn Sakuma is with the College of Public Health and Human Sciences, Oregon State University, Corvallis. Mark S. Clanton is with the TMF Health Quality Institute, Austin, TX.
Am J Public Health. 2015 Jun;105(6):1237-45. doi: 10.2105/AJPH.2014.302492. Epub 2015 Apr 16.
We examined biomarkers of tobacco smoke exposure among Native Hawaiians, Filipinos, and Whites, groups that have different lung cancer risk.
We collected survey data and height, weight, saliva, and carbon monoxide (CO) levels from a sample of daily smokers aged 18-35 (n = 179). Mean measures of nicotine, cotinine, cotinine/cigarettes per day ratio, trans 3' hydroxycotinine, the nicotine metabolite ratio (NMR), and expired CO were compared among racial/ethnic groups.
The geometric means for cotinine, the cotinine/cigarettes per day ratio, and CO did not significantly differ among racial/ethnic groups in the adjusted models. After adjusting for gender, body mass index, menthol smoking, Hispanic ethnicity, and number of cigarettes smoked per day, the NMR was significantly higher among Whites than among Native Hawaiians and Filipinos (NMR = 0.33, 0.20, 0.19, P ≤ .001). The NMR increased with increasing White parental ancestry. The NMR was not significantly correlated with social-environmental stressors.
Racial/ethnic groups with higher rates of lung cancer had slower nicotine metabolism than Whites. The complex relationship between lung cancer risk and nicotine metabolism among racial/ethnic groups needs further clarification.
我们研究了夏威夷原住民、菲律宾人和白人（这些群体患肺癌风险不同）中烟草烟雾暴露的生物标志物。
我们从18 - 35岁的每日吸烟者样本（n = 179）中收集了调查数据、身高、体重、唾液和一氧化碳（CO）水平。比较了种族/族裔群体之间尼古丁、可替宁、每日可替宁/香烟比值、反式3'-羟基可替宁、尼古丁代谢物比值（NMR）和呼出CO的平均测量值。
在调整模型中，种族/族裔群体之间可替宁、每日可替宁/香烟比值和CO的几何平均值没有显著差异。在调整性别、体重指数、薄荷醇吸烟、西班牙裔种族和每日吸烟支数后，白人的NMR显著高于夏威夷原住民和菲律宾人（NMR分别为0.33、0.20、0.19，P≤0.001）。NMR随着白人父母血统的增加而升高。NMR与社会环境压力源没有显著相关性。
肺癌发病率较高的种族/族裔群体的尼古丁代谢比白人慢。种族/族裔群体中肺癌风险与尼古丁代谢之间的复杂关系需要进一步阐明。
