Esteghamati Alireza, Mazaheri Tina, Vahidi Rad Mona, Noshad Sina
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran.
Int J Endocrinol Metab. 2015 Apr 20;13(2):e19678. doi: 10.5812/ijem.19678. eCollection 2015 Apr.
Obesity and its associated morbidities pose a major health hazard to the public. Despite a multiplex of available diet and exercise programs for losing and maintaining weight, over the past years, interest in the use of complementary and alternative medicine (CAM) for obesity treatment has greatly increased.
We searched PubMed, Google scholar and the Cochrane databases for systemic reviews, review articles, meta-analysis and randomized clinical trials up to December 2013.
In this review, the efficacy and safety of the more commonly used CAM methods for the treatment of obesity, namely herbal supplements, acupuncture, and non-invasive body-contouring, are briefly discussed. The evidence supporting the effectiveness and safety of these methods is either lacking or point to a negligible clinical benefit, barely surpassing that of the placebo. Furthermore, several limitations are observed in the available scientific literature. These shortcomings include, without being limited to, uncontrolled trial designs, non-random allocation of subjects to treatment arms, small number of patients enrolled, short durations of follow-up, and ambiguous clinical and laboratory endpoints.
Further investigations are necessary to accurately determine the efficacy, safety, standard dosage/procedure, and potential side effects of the various CAM methods currently in use.
肥胖及其相关疾病对公众健康构成重大危害。尽管有多种可用的饮食和运动计划用于减肥和维持体重，但在过去几年中，使用补充和替代医学（CAM）治疗肥胖的兴趣大幅增加。
我们检索了PubMed、谷歌学术和考克兰数据库，查找截至2013年12月的系统评价、综述文章、荟萃分析和随机临床试验。
在本综述中，简要讨论了治疗肥胖更常用的补充和替代医学方法的疗效和安全性，即草药补充剂、针灸和非侵入性身体塑形。支持这些方法有效性和安全性的证据要么缺乏，要么表明临床益处微不足道，几乎不超过安慰剂。此外，在现有科学文献中观察到几个局限性。这些缺点包括但不限于非对照试验设计、受试者非随机分配至治疗组、纳入患者数量少、随访时间短以及临床和实验室终点不明确。
有必要进行进一步研究，以准确确定目前使用的各种补充和替代医学方法的疗效、安全性、标准剂量/程序和潜在副作用。
