Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
J Thromb Haemost. 2015 Jul;13(7):1254-63. doi: 10.1111/jth.12982. Epub 2015 Jun 1.
To determine the age- and sex-specific prevalence and determinants of retinal vein occlusions (RVOs) in a large population-based German cohort.
The investigation included 15,010 participants (aged 35-74 years) from the Gutenberg Health Study. We determined the prevalence of RVO (central retinal vein occlusion [CRVO] and branch retinal vein occlusion [BRVO]) for the local population by assessing fundus photographs of 12 954 (86.3%; 49.8% women and 50.2% men) participants. Further, we analyzed the associations of RVO with cardiovascular, anthropometric, and ophthalmic parameters.
The weighted prevalences of RVO, CRVO, and BRVO were 0.40%, 0.08%, and 0.32%, respectively. Men were 1.7 times more frequently affected by RVO than were women. Prevalence of RVO was 0.2% in participants aged 35-44 and 45-54 years, respectively, 0.48% in those aged 55-64 years, and 0.92% in those aged 65-74 years. Of persons with RVO, 91.5% had one or more cardiovascular risk factor or disease vs. 75.9% of persons without RVO. BRVO was associated with arterial hypertension (odds ratio 2.69, 95% confidence interval 1.27-5.70) and atrial fibrillation (3.37, 1.24-9.12) and CRVO with higher age (7.02, 1.63-30.19) and a family history of stroke (4.64, 1.18-18.25). Median visual acuity (base 10 logarithm of minimum angle of resolution) was 0.2 in persons with RVO vs. 0.05 in those without.
The prevalence of RVO in this German population was 0.4%, and men were 1.7 times more frequently affected than women. CRVO was associated with higher age and a family history of stroke, and BRVO was associated with arterial hypertension and atrial fibrillation.
在一个大型基于人群的德国队列中，确定视网膜静脉闭塞（RVO）的年龄和性别特异性患病率和决定因素。
该研究纳入了来自哥廷根健康研究的 15010 名（年龄 35-74 岁）参与者。我们通过评估 12954 名（49.8%为女性，50.2%为男性）参与者的眼底照片，确定了当地人群中 RVO（中央视网膜静脉阻塞[CRVO]和分支视网膜静脉阻塞[BRVO]）的患病率。此外，我们分析了 RVO 与心血管、人体测量和眼科参数的关联。
RVO、CRVO 和 BRVO 的加权患病率分别为 0.40%、0.08%和 0.32%。男性患 RVO 的频率是女性的 1.7 倍。35-44 岁和 45-54 岁参与者的 RVO 患病率分别为 0.2%，55-64 岁参与者的患病率为 0.48%，65-74 岁参与者的患病率为 0.92%。患有 RVO 的人中，91.5%有一个或多个心血管危险因素或疾病，而没有 RVO 的人中，这一比例为 75.9%。BRVO 与高血压（比值比 2.69，95%置信区间 1.27-5.70）和心房颤动（3.37，1.24-9.12）相关，CRVO 与年龄较大（7.02，1.63-30.19）和中风家族史（4.64，1.18-18.25）相关。患有 RVO 的人的中位视力（10 进制最小分辨角对数）为 0.2，而没有 RVO 的人的视力为 0.05。
在该德国人群中，RVO 的患病率为 0.4%，男性患病率是女性的 1.7 倍。CRVO 与年龄较大和中风家族史相关，BRVO 与高血压和心房颤动相关。
