Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, VIC, Australia.
Ophthalmology. 2010 Feb;117(2):313-9.e1. doi: 10.1016/j.ophtha.2009.07.017.
To summarize the prevalence of retinal vein occlusion (RVO) from studies in the United States, Europe, Asia, and Australia.
Pooled analysis using individual population-based data.
Individual participant data from population-based studies around the world that had ascertained RVO from fundus photographs.
Each study provided data on branch RVO and central RVO by age, sex, and ethnicity. Prevalence rates were directly age and sex standardized to the 2008 world population aged 30 years and older. Estimates were calculated by study and, after pooling, by ethnicity. Summary estimates included studies in which RVO was assessed from fundus photographs on >or=2 fields of both eyes.
Any RVO, CRVO, or BRVO.
The combined pooled data contained 68,751 individuals from 15 studies, with participants' ages ranging from 30 to 101 years. In analyses of 11 studies that assessed >or=2 fundus fields of both eyes (n=49,869), the age- and sex-standardized prevalence was 5.20 per 1000 (confidence interval [CI], 4.40-5.99) for any RVO, 4.42 per 1000 (CI, 3.65-5.19) for BRVO, and 0.80 per 1000 (CI, 0.61-0.99) for CRVO. Prevalence varied by race/ethnicity and increased with age, but did not differ by gender. The age- and sex-standardized prevalence of any RVO was 3.7 per 1000 (CI, 2.8-4.6) in whites (5 studies), 3.9 per 1000 (CI, 1.8-6.0) in blacks (1 study), 5.7 per 1000 (CI, 4.5-6.8) in Asians (6 studies), and 6.9 per 1000 (CI, 5.7-8.3) in Hispanics (3 studies). Prevalence for CRVO was lower than BRVO in all ethnic populations. On the basis of these data, an estimated 16.4 million (CI, 13.9-18.9) adults are affected by RVO, with 2.5 million (CI, 1.9-3.1) affected by CRVO and 13.9 million (CI, 11.5-16.4) affected by BRVO. Study limitations include non-uniform sampling frames in identifying study participants and in acquisition and grading of RVO data.
Our study provides summary data on the prevalence of RVO and suggests that approximately 16 million people may have this condition. Research on preventive and treatment strategies for this sight-threatening eye disease is needed.
总结美国、欧洲、亚洲和澳大利亚的研究中视网膜静脉阻塞（RVO）的患病率。
使用基于人群的个体数据进行汇总分析。
来自世界各地的基于人群的研究中的个体参与者数据，这些研究通过眼底照片确定了 RVO。
每项研究均按年龄、性别和种族提供分支 RVO 和中央 RVO 的数据。患病率通过与 2008 年世界 30 岁及以上人口年龄和性别相匹配进行直接标准化。根据研究进行了估计，然后按种族进行了汇总。汇总估计包括 RVO 通过评估来自>或=双眼 2 个视野眼底照片的研究。
任何 RVO、CRVO 或 BRVO。
合并的汇总数据包含来自 15 项研究的 68751 名个体，参与者年龄在 30 至 101 岁之间。在分析评估了>或=双眼 2 个眼底视野的 11 项研究（n=49869）中，任何 RVO 的年龄和性别标准化患病率为每 1000 人 5.20（置信区间[CI]，4.40-5.99），BRVO 为每 1000 人 4.42（CI，3.65-5.19），CRVO 为每 1000 人 0.80（CI，0.61-0.99）。患病率因种族/族裔而异，并随年龄增长而增加，但与性别无关。任何 RVO 的年龄和性别标准化患病率在白人（5 项研究）中为每 1000 人 3.7（CI，2.8-4.6），在黑人（1 项研究）中为每 1000 人 3.9（CI，1.8-6.0），在亚洲人（6 项研究）中为每 1000 人 5.7（CI，4.5-6.8），在西班牙裔（3 项研究）中为每 1000 人 6.9（CI，5.7-8.3）。在所有种族人群中，CRVO 的患病率均低于 BRVO。基于这些数据，估计有 1640 万人（CI，13.9-18.9）患有 RVO，其中 250 万人（CI，1.9-3.1）患有 CRVO，1390 万人（CI，11.5-16.4）患有 BRVO。研究的局限性包括在确定研究参与者以及 RVO 数据的获取和分级方面，采样框架不统一。
我们的研究提供了 RVO 患病率的汇总数据，并表明可能有大约 1600 万人患有这种疾病。需要研究这种威胁视力的眼病的预防和治疗策略。
