钯催化下，利用硫粉、吲哚和环己酮通过脱水-脱氢双C-H硫化反应形成苯并噻吩并[2,3-b]吲哚。

Palladium-catalyzed benzothieno[2,3-b]indole formation via dehydrative-dehydrogenative double C-H sulfuration using sulfur powder, indoles and cyclohexanones.

作者信息

Liao Yunfeng, Peng Yi, Qi Hongrui, Deng Guo-Jun, Gong Hang, Li Chao-Jun

机构信息

Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China.

出版信息

Chem Commun (Camb). 2015 Jan 21;51(6):1031-4. doi: 10.1039/c4cc08370a.

DOI:10.1039/c4cc08370a

PMID:25466557

Abstract

Palladium-catalyzed C-S bond formation via dehydrative-dehydrogenative double C-H sulfuration using sulfur powder is described. The dehydrogenated intermediates of cyclohexanones can be trapped to act as efficient aryl sources under an oxygen atmosphere. This procedure provides a novel approach for the preparation of benzothieno[2,3-b]indoles.

摘要

描述了通过使用硫粉进行脱水-脱氢双C-H硫化反应，钯催化形成C-S键的过程。环己酮的脱氢中间体在氧气气氛下可被捕获，作为有效的芳基源。该方法为苯并噻吩并[2,3-b]吲哚的制备提供了一种新途径。