van Ingen Jakko, van der Lee Henrich A L, Rijs Antonius J M M, Snelders Eveline, Melchers Willem J G, Verweij Paul E
Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.
Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands
J Clin Microbiol. 2015 Jul;53(7):2343-5. doi: 10.1128/JCM.00502-15. Epub 2015 Apr 22.
High-level pan-azole-resistant Aspergillus fumigatus was recovered from four patients with chronic lung disease. In one patient, the development of progressive resistance followed long-term azole therapy and switching between antifungal azoles. The high-level pan-azole-resistant phenotypes were not associated with a specific cyp51A gene mutation. New strategies that avoid the development of progressive azole resistance are needed.
从4例慢性肺病患者中分离出了对泛唑类高度耐药的烟曲霉。在1例患者中，长期唑类治疗以及在抗真菌唑类之间换药后出现了逐步耐药的情况。高度泛唑耐药表型与特定的cyp51A基因突变无关。需要采取避免逐步产生唑类耐药的新策略。
