Nacer Renato Silva, Silva Baldomero Antonio Kato da, Poppi Rodrigo Ré, Silva Dheywid Karlos Mattos, Cardoso Vinicius Saura, Delben José Renato Jurkevicz, Delben Angela Antonia Sanches Tardivo
UFMS, Campo Grande, MS, Brazil.
UFPI, Parnaiba, PI, Brazil.
Acta Cir Bras. 2015 Apr;30(4):255-63. doi: 10.1590/S0102-865020150040000004. Epub 2015 Apr 1.
To evaluate the biocompatibility and osteogenesis of castor oil polymer doped with SiO2 or BaTiO3 nanoparticles.
Twenty four male rats Wistar were submitted to bone defect filled with castor oil polymer. The animals were distributed in two experimental groups had been formed with 12 animals each: Group 1 - Castor oil polymer doped with 0.30 grams of SiO2 replacing 0.30 grams of CaCO3. Group 2 - Castor oil polymer doped with 0.30 grams of BaTiO3 replacing 0.30 grams of CaCO3. Euthanasia occurred 30 and 60 days after surgery and the femurs were sent to histological analysis and MEV.
The implants were biocompatible and allowed for progressive osteogenesis through osteoconduction in both observation periods. There was significant bone neoformation at 30 and 60 days in both groups within the histomorphometric evaluation, but group 1's osteogenesis was lesser in the 30 and 60-day periods observed when compared to the animals of group 2. The MEV morphometric evaluation evidenced a lesser percentage of osseous tissue filling within the BaTiO2-doped polymer.
The castor oil polymer doped with SiO2 or BaTiO3 remained biocompatible and allowed for progressive osteogenesis in both observation periods.
评估掺杂二氧化硅（SiO₂）或钛酸钡（BaTiO₃）纳米颗粒的蓖麻油聚合物的生物相容性和成骨作用。
将24只雄性Wistar大鼠制成骨缺损并填充蓖麻油聚合物。动物被分为两个实验组，每组12只：第1组 - 掺杂0.30克SiO₂替代0.30克碳酸钙的蓖麻油聚合物。第2组 - 掺杂0.30克BaTiO₃替代0.30克碳酸钙的蓖麻油聚合物。术后30天和60天实施安乐死，将股骨送去进行组织学分析和扫描电子显微镜（MEV）检查。
在两个观察期内，植入物均具有生物相容性，并通过骨传导实现渐进性成骨。在组织形态计量学评估中，两组在30天和60天时均有明显的骨新形成，但与第2组动物相比，第1组在观察的30天和60天期间成骨作用较弱。扫描电子显微镜形态计量学评估表明，掺杂BaTiO₂的聚合物内骨组织填充百分比更低。
掺杂SiO₂或BaTiO₃的蓖麻油聚合物在两个观察期内均保持生物相容性并实现渐进性成骨。
