PECAM-1基因Leu125Val多态性与冠心病风险的关联：一项荟萃分析。
Association of Leu125Val polymorphisms in the PECAM-1 gene with the risk of coronary heartdisease: a meta-analysis.
作者信息
Xia Tao, Liu Xin, Du Chang Jiang, Jin Xin, Kong Xiang Qian, Li Gang
机构信息
Department of Cardiac Surgery, Shandong Provincial Hospital Affiliated to Shandong University 324 Jing Wu Wei Qi Road, Jinan 250021, China ; Department of Cardiovascular Surgery, The Central Hospital of Tai'an 29 Long Tan Road, Tai'an 271000, China.
Department of Ultrasound Branch, The Central Hospital of Tai'an 29 Long Tan Road, Tai'an 271000, China.
出版信息
Int J Clin Exp Med. 2015 Feb 15;8(2):2219-25. eCollection 2015.
OBJECTIVE
Several published literatures investigated the relation between a polymorphism (Leul25Val) in platelet endothelial cell adhesion molecule-1 (PECAM-1) gene and risk of coronary heart disease (CHD) and did not reach the same conclusion. To shed light on these inconclusive findings, we performed a meta-analysis of studies relating the PECAM-1 genetic polymorphism (Leul25Val) to the risk of CHD.
METHODS
We identified literatures by searching PubMed, EMBASE, Chinese National Knowledge Infrastructure databases (CNKI) and Wanfang database in China. Data from eligible studies were extracted for meta-analysis. CHD risk associated with PECAM-1 genetic polymorphism (Leul25Val) was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). The software Review Manager (Version 5.2) was used for meta-analysis. Publication bias was tested by funnel plot.
RESULTS
A total of 15 studies comprising 3696 cases and 3940 controls fulfilled the inclusion criteria. Our results did not show that Leul25Val polymorphism in PECAM-1 gene was associated with the risk of CHD [(LL+LV) vs VV, OR = 1.15, 95% CI: 0.84-1.56, P = 0.38; (VV+LV) vs LL, OR = 0.96, 95% CI: 0.79-1.17, P = 0.69; V vs L, OR = 1.08, 95% CI: 0.92-1.27, P = 0.80, respectively] by a meta-analysis.
CONCLUSION
The results of our meta-analysis suggested that Leul25Val polymorphism in PECAM-1 gene is not a susceptibility marker of CHD.
目的
多项已发表的文献研究了血小板内皮细胞黏附分子-1（PECAM-1）基因中的一种多态性（Leu125Val）与冠心病（CHD）风险之间的关系，但未得出相同结论。为了阐明这些不确定的发现，我们对有关PECAM-1基因多态性（Leu125Val）与CHD风险的研究进行了荟萃分析。
方法
我们通过检索PubMed、EMBASE、中国国家知识基础设施数据库（CNKI）和中国万方数据库来识别文献。提取符合条件的研究数据进行荟萃分析。通过合并比值比（OR）和95%置信区间（95%CI）来估计与PECAM-1基因多态性（Leu125Val）相关的CHD风险。使用Review Manager软件（版本5.2）进行荟萃分析。通过漏斗图检验发表偏倚。
结果
共有15项研究，包括3696例病例和3940例对照符合纳入标准。我们的结果未显示PECAM-1基因中的Leu125Val多态性与CHD风险相关[（LL+LV）与VV相比，OR = 1.15，95%CI：0.84-1.56，P = 0.38；（VV+LV）与LL相比，OR = 0.96，95%CI：0.79-1.17，P = 0.69；V与L相比，OR = 1.08，95%CI：0.92-1.27，P = 0.80]。
结论
我们的荟萃分析结果表明，PECAM-1基因中的Leu125Val多态性不是CHD的易感性标志物。
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