Department of Immunology, University of Toronto, Toronto, Ontario, Canada; Division Models of Inflammation, Leibniz Center for Medicine and Biosciences, Research Center Borstel, Borstel, Germany; and Institute for Experimental Medicine, University of Kiel, Kiel, Germany
Department of Immunology, University of Toronto, Toronto, Ontario, Canada;
Physiology (Bethesda). 2015 May;30(3):241-50. doi: 10.1152/physiol.00025.2014.
The NOD-like receptors (NLRs) are cytosolic pattern-recognition receptors, which are critically involved in mucosal immune defense. The association of the NLR, NOD2, with inflammatory bowel disease first pointed to the NLRs potential function as guardians of the intestinal barrier. Since then, several studies have emphasized the importance of NLRs in maintaining gut homeostasis and intestinal infections, and in shaping the microbiota. In this review, we will highlight the function of NLRs in intestinal inflammation.
NOD 样受体（NLRs）是细胞溶质模式识别受体，在黏膜免疫防御中起关键作用。NLR、NOD2 与炎症性肠病的关联首次表明 NLR 作为肠道屏障守护者的潜在功能。从那时起，几项研究强调了 NLR 在维持肠道内稳态和肠道感染以及塑造微生物群中的重要性。在这篇综述中，我们将重点介绍 NLR 在肠道炎症中的作用。
