Institut Pasteur, Biology and Genetics of Bacterial Cell Wall, Avenir Group INSERM, Paris, France.
J Leukoc Biol. 2011 Sep;90(3):471-82. doi: 10.1189/jlb.0411183. Epub 2011 Jun 7.
NLRs have been shown in a number of models to protect against microbial infection through their ability to participate in "pattern recognition" and their triggering of inflammatory pathways to control infection. Over the past few years, however, the role of NLRs, especially Nod1, Nod2, and NLRP3, in intestinal homeostasis has been highlighted. Indeed, these specific NLRs have been implicated in IBD, in particular, the association of Nod2 with CD, yet a clear understanding of how dysfunctional NLR activation leads to aberrant inflammation is still the focus of much investigation. In this review, we will examine how NLRs participate in the maintenance of gut homeostasis and how upset of this regulation can tip the balance toward chronic inflammation and intestinal cancer.
NLRs 在许多模型中被证明能够通过参与“模式识别”和触发炎症途径来控制感染，从而起到预防微生物感染的作用。然而，在过去的几年中，NLRs（尤其是 Nod1、Nod2 和 NLRP3）在肠道稳态中的作用已被强调。事实上，这些特定的 NLRs 与 IBD 有关，尤其是 Nod2 与 CD 的关联，但 NLR 激活功能障碍如何导致异常炎症的确切机制仍然是许多研究的重点。在这篇综述中，我们将探讨 NLRs 如何参与维持肠道稳态，以及这种调节的失调如何导致慢性炎症和肠道癌症。
