Christou Chris, Oliver Rema A, Rawlinson John, Walsh William R
Surgical and Orthopaedic Research Laboratory, Prince of Wales Clinical School, University of New South Wales, Level 1 Clinical Sciences Building Avoca St, Randwick 2031 Australia.
Surgical and Orthopaedic Research Laboratory, Prince of Wales Clinical School, University of New South Wales, Level 1 Clinical Sciences Building Avoca St, Randwick 2031 Australia.
Res Vet Sci. 2015 Jun;100:252-6. doi: 10.1016/j.rvsc.2015.04.006. Epub 2015 Apr 17.
Fentanyl delivered via a transdermal patch has the potential to decrease the need for post-operative handling of sheep undergoing surgical procedures. Two studies were performed to test: (1) the ideal timing for the application of pre-emptive analgesic patches and (2) the efficacy of a 2 µg/kg/h dose, as extrapolated from other species. The first study had sheep divided into two groups. Group 1 had a fentanyl patch applied for 24 h prior to a patch change and group 2 had a fentanyl patch applied 72 h prior to a change. The second study applied the results obtained in the first and tested the efficacy of 2 µg/kg/h as an effective dose in an orthopaedic surgical environment. Results indicated that the ideal time for pre-emptive fentanyl patch administration is 24-36 h prior to surgery and that 2 µg/kg/h is an effective minimum therapeutic dose rate for the use of fentanyl as an analgesic in an orthopaedic surgical environment.
通过透皮贴剂给药的芬太尼有可能减少接受外科手术的绵羊术后护理的需求。进行了两项研究以测试：（1）预防性镇痛贴剂的理想给药时间，以及（2）从其他物种推断出的2μg/kg/h剂量的疗效。第一项研究将绵羊分为两组。第1组在更换贴剂前24小时应用芬太尼贴剂，第2组在更换前72小时应用芬太尼贴剂。第二项研究应用了第一项研究获得的结果，并测试了2μg/kg/h作为骨科手术环境中有效剂量的疗效。结果表明，预防性芬太尼贴剂给药的理想时间是手术前24-36小时，并且2μg/kg/h是芬太尼在骨科手术环境中用作镇痛药的有效最低治疗剂量率。
