Ding Lingling, Liu Zhidong, Aggrey Mike Okweesi, Li Chunhua, Chen Jing, Tong Ling
Tianjin State Key Laboratory of Modern Chinese Medicine, No. 88 Yuquan Road, Nankai District, Tianjin 300193, P.R. China.
Mini Rev Med Chem. 2015;15(7):529-42. doi: 10.2174/138955751507150424104334.
Along with the exuberant development of nanotechnology, a large number of nanoformulations or non materials are successfully applied in the clinics, biomedicine, cosmetics and industry. Despite some unique advantages of nanoformulations, there exist potentially worrying toxic effects, particularly those related to metal and metal-containing nanoparticles (NPs). Although various researches have been conducted to assess the metallic and metal-containing nanoparticles toxic effects, only little is known about the toxicity expressive types and evaluation, reasons and mechanisms, influencing factors and research methods of metal and metal-containing nanotoxicity. Therefore, it is of importance to acquire a better understanding of metal and metal-containing nanoparticles toxicity for medical application. This review presents a summary on the metal and metal-containing nanoparticles toxicity research progress consulting relevant literature.
随着纳米技术的蓬勃发展，大量的纳米制剂或纳米材料已成功应用于临床、生物医学、化妆品及工业领域。尽管纳米制剂具有一些独特优势，但也存在潜在的令人担忧的毒性效应，尤其是与金属及含金属纳米颗粒（NPs）相关的毒性。虽然已开展了各种研究来评估金属及含金属纳米颗粒的毒性效应，但对于金属及含金属纳米毒性的毒性表现类型及评估、原因及机制、影响因素和研究方法，人们了解甚少。因此，更好地了解金属及含金属纳米颗粒在医学应用中的毒性具有重要意义。本综述参考相关文献，对金属及含金属纳米颗粒的毒性研究进展进行了总结。
