Baird Nicholas L, Bowlin Jacqueline L, Hotz Taylor J, Cohrs Randall J, Gilden Don
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
J Virol. 2015 Jul;89(14):7425-7. doi: 10.1128/JVI.00594-15. Epub 2015 May 6.
Infection of human neurons in vitro with varicella-zoster virus (VZV) at a low multiplicity of infection does not result in a cytopathic effect (CPE) within 14 days postinfection (dpi), despite production of infectious virus. We showed that by 28 dpi a CPE ultimately developed in infected neurons and that interferon gamma inhibited not only the CPE but also VZV DNA accumulation, transcription, and virus production, thereby prolonging the life of VZV-infected neurons.
在体外以低感染复数用人神经元感染水痘带状疱疹病毒（VZV），在感染后14天内不会产生细胞病变效应（CPE），尽管会产生传染性病毒。我们发现，到感染后28天时，受感染的神经元最终会出现CPE，并且干扰素γ不仅抑制CPE，还抑制VZV DNA积累、转录和病毒产生，从而延长VZV感染神经元的存活时间。
