May D C, Miller M R, Rapp F
Intervirology. 1977;8(2):83-91. doi: 10.1159/000148882.
Phosphonoacetic acid (PAA) was found to inhibit in vitro varicella-zoster virus (VZV) replication. At 100 microng/ml, PAA blocked the development and spread of VZV cytopathology in both growing and contact-inhibited cultures. Formation of virus plaques by infected cells and cell-free virus was effectively blocked at concentrations as low as 25 microng/ml. The development of nuclear and cytoplasmic virus antigens was also inhibited by PAA. Inhibition by PAA suggests that VZV DNA replication, like that of other herpes-viruses, involves a virus-specific DNA polymerase.
膦甲酸钠（PAA）被发现可在体外抑制水痘带状疱疹病毒（VZV）复制。在100微克/毫升时，PAA在生长型和接触抑制型培养物中均能阻断VZV细胞病变的发展和扩散。在低至25微克/毫升的浓度下，感染细胞和无细胞病毒形成病毒斑的过程均被有效阻断。PAA还抑制了核病毒抗原和胞质病毒抗原的产生。PAA的抑制作用表明，VZV DNA复制与其他疱疹病毒一样，涉及一种病毒特异性DNA聚合酶。
