Marks D F, MacAvoy M G
Middlesex Polytechnic, UK.
Psychopharmacology (Berl). 1989;99(3):397-401. doi: 10.1007/BF00445566.
The effect of delta 9-tetrahydrocannabinol (delta 9-THC) and alcohol, singly and in combination, on divided attention performance was investigated in cannabis users and non-users who were matched for alcohol use. Both cannabis and alcohol produced decrements in central and peripheral signal detections. Drug and alcohol effects were greater for signal presentations in the periphery. Cannabis users were less impaired in peripheral signal detection than non-users while intoxicated by cannabis and/or alcohol. These findings suggest the development of tolerance and cross-tolerance in regular cannabis users and/or the ability to compensate for intoxication effects.
研究了 Δ⁹-四氢大麻酚（Δ⁹-THC）和酒精单独及联合使用对注意力分散表现的影响，研究对象为在饮酒方面相匹配的大麻使用者和非使用者。大麻和酒精都会使中枢和外周信号检测能力下降。药物和酒精对外周信号呈现的影响更大。在因大麻和/或酒精而醉酒时，大麻使用者在外周信号检测方面受到的损害比非使用者小。这些发现表明，经常使用大麻的人会产生耐受性和交叉耐受性，和/或具备补偿中毒影响的能力。
