Fisher Jonathan, Kramer Anne-Marijn, Gustafsson Kenth, Anderson John
Section of Cancer; UCL Institute of Child Health ; London, UK.
Section of Molecular and Cellular Immunology; UCL Institute of Child Health ; London, UK.
Oncoimmunology. 2014 Dec 23;4(3):e973808. doi: 10.4161/2162402X.2014.973808. eCollection 2015 Mar.
Gamma delta T cells (γδT) are potent mediators of antitumor cytotoxicity and have shown promising efficacy in early phase clinical trials. Most is known about the tumoricidal properties of cells bearing the Vδ2 T cell receptor chain, but recent studies have demonstrated that cells with the Vδ1 chain and those with neither Vδ1 nor Vδ2 chains have properties which may make them more attractive anticancer effectors in adoptive immunotherapy.
γδT细胞是抗肿瘤细胞毒性的有效介质，并且在早期临床试验中已显示出有前景的疗效。关于携带Vδ2 T细胞受体链的细胞的杀肿瘤特性了解最多，但最近的研究表明，具有Vδ1链的细胞以及既没有Vδ1链也没有Vδ2链的细胞具有一些特性，这可能使它们在过继性免疫疗法中成为更具吸引力的抗癌效应细胞。
