Eason J, Markowe H L
Department of Anaesthetics, King's College Hospital, Denmark Hill, London, U.K.
Respir Med. 1989 May;83(3):219-26. doi: 10.1016/s0954-6111(89)80035-6.
Aminophylline administration was compared in 43 patients who died from asthma and 43 matched controls who were admitted, suffering from acute asthma, to hospitals in the North East Thames Region. A computer program, which used information about individual characteristics, medical history and drug intake, was employed to calculate the serum theophylline levels which were likely to have resulted from the hospital treatment each patient received. Toxic theophylline levels were estimated to have occurred in 21% (9/43) of fatal cases and 7% (3/43) controls. Details of four patients who died when their serum theophylline levels were likely to have been very high are presented. Six fatal cases suffered gastro-intestinal bleeds during their final illness: four of these had theophylline levels which were calculated to have been toxic at the time of bleeding.
对43例死于哮喘的患者与43例相匹配的对照者进行了氨茶碱给药情况的比较，这些对照者因急性哮喘发作被收入泰晤士河东北部地区的医院。利用一个计算机程序，该程序运用了有关个体特征、病史和药物摄入的信息，来计算每位患者接受的医院治疗可能导致的血清茶碱水平。据估计，21%（9/43）的致命病例和7%（3/43）的对照者出现了茶碱中毒水平。文中介绍了4例血清茶碱水平可能非常高时死亡患者的详细情况。6例致命病例在其终末期疾病期间出现了胃肠道出血：其中4例在出血时的茶碱水平经计算已达到中毒水平。
