Sjölin J, Stjernström H, Arturson G, Andersson E, Friman G, Larsson J
Department of Infectious Diseases, University Hospital, Uppsala, Sweden.
Am J Clin Nutr. 1989 Dec;50(6):1407-14. doi: 10.1093/ajcn/50.6.1407.
This investigation was undertaken to determine the splanchnic exchange of 3-methylhistidine (3MH) in infection. Hepatic vein, femoral vein, and radial artery catheterizations were performed in 12 febrile patients with infections of varying severity. Differences in arteriovenous 3MH, analyzed by high-performance liquid chromatography, were multiplied by the plasma flows, determined by a dye dilution technique. The mean splanchnic efflux was 0.062 +/- 0.180 mumol/min (mean +/- SD) with uptake occurring in five patients. The splanchnic uptake was significantly (p less than 0.001) correlated with the urinary 3MH excretion and the peripheral release from the leg. It is concluded that in human infection, splanchnic 3MH release is low and in patients with high rates of myofibrillar catabolism there may even be an uptake. The urinary 3MH excretion is still a marker of myofibrillar protein breakdown because it correlates well with the release from the leg, regardless of whether the patient has a splanchnic uptake or a release.
本研究旨在确定感染时内脏对3-甲基组氨酸（3MH）的交换情况。对12例患有不同严重程度感染的发热患者进行肝静脉、股静脉和桡动脉插管。通过高效液相色谱分析的动静脉3MH差异乘以通过染料稀释技术测定的血浆流量。平均内脏流出量为0.062±0.180μmol/分钟（平均值±标准差），5例患者出现摄取。内脏摄取与尿3MH排泄及腿部外周释放显著相关（p<0.001）。结论是，在人类感染中，内脏3MH释放较低，在肌原纤维分解代谢率高的患者中甚至可能出现摄取。尿3MH排泄仍然是肌原纤维蛋白分解的标志物，因为它与腿部释放密切相关，无论患者是内脏摄取还是释放。
