Titmarsh Helen, Kilpatrick Scott, Sinclair Jennifer, Boag Alisdair, Bode Elizabeth F, Lalor Stephanie M, Gaylor Donna, Berry Jacqueline, Bommer Nicholas X, Gunn-Moore Danielle, Reed Nikki, Handel Ian, Mellanby Richard J
Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Roslin, Midlothian, United Kingdom.
Specialist Assay Laboratory (Vitamin D), Clinical Biochemistry, Manchester Royal Infirmary, Manchester, United Kingdom.
PLoS One. 2015 May 13;10(5):e0125997. doi: 10.1371/journal.pone.0125997. eCollection 2015.
Vitamin D insufficiency, defined as low serum concentrations of the major circulating form of vitamin D, 25 hydroxyvitamin D (25(OH)D), has been associated with the development of numerous infectious, inflammatory, and neoplastic disorders in humans. In addition, vitamin D insufficiency has been found to be predictive of mortality for many disorders. However, interpretation of human studies is difficult since vitamin D status is influenced by many factors, including diet, season, latitude, and exposure to UV radiation. In contrast, domesticated cats do not produce vitamin D cutaneously, and most cats are fed a commercial diet containing a relatively standard amount of vitamin D. Consequently, domesticated cats are an attractive model system in which to examine the relationship between serum 25(OH)D and health outcomes. The hypothesis of this study was that vitamin D status would predict short term, all-cause mortality in domesticated cats. Serum concentrations of 25(OH)D, together with a wide range of other clinical, hematological, and biochemical parameters, were measured in 99 consecutively hospitalised cats. Cats which died within 30 days of initial assessment had significantly lower serum 25(OH)D concentrations than cats which survived. In a linear regression model including 12 clinical variables, serum 25(OH)D concentration in the lower tertile was significantly predictive of mortality. The odds ratio of mortality within 30 days was 8.27 (95% confidence interval 2.54-31.52) for cats with a serum 25(OH)D concentration in the lower tertile. In conclusion, this study demonstrates that low serum 25(OH)D concentration status is an independent predictor of short term mortality in cats.
维生素D不足被定义为血清中维生素D的主要循环形式——25羟维生素D（25(OH)D）浓度较低，它与人类多种感染性、炎症性和肿瘤性疾病的发生有关。此外，维生素D不足已被发现可预测多种疾病的死亡率。然而，由于维生素D状态受多种因素影响，包括饮食、季节、纬度和紫外线辐射暴露，因此对人体研究的解读较为困难。相比之下，家养猫不会通过皮肤合成维生素D，并且大多数猫食用的是含有相对标准量维生素D的商业饮食。因此，家养猫是一个有吸引力的模型系统，可用于研究血清25(OH)D与健康结果之间的关系。本研究的假设是维生素D状态可预测家养猫的短期全因死亡率。对99只连续住院的猫测量了血清25(OH)D浓度以及一系列其他临床、血液学和生化参数。在初次评估后30天内死亡的猫，其血清25(OH)D浓度显著低于存活的猫。在一个包含12个临床变量的线性回归模型中，处于较低三分位数的血清25(OH)D浓度可显著预测死亡率。血清25(OH)D浓度处于较低三分位数的猫在30天内死亡的比值比为8.27（95%置信区间2.54 - 31.52）。总之，本研究表明血清25(OH)D浓度低是猫短期死亡率的独立预测因素。
