Lalor S, Schwartz A M, Titmarsh H, Reed N, Tasker S, Boland L, Berry J, Gunn-Moore D, Mellanby R J
The Royal (Dick) School of Veterinary Studies, Division of Clinical Veterinary Sciences, University of Edinburgh, Edinburgh, UK.
J Vet Intern Med. 2014 Mar-Apr;28(2):351-5. doi: 10.1111/jvim.12294. Epub 2014 Jan 16.
Inflammatory bowel disease (IBD) and intestinal small cell lymphoma (ISCL) are common diseases in cats. The prevalence of alterations in the serum concentrations of fat soluble vitamins, such as vitamin D, in cats with IBD and ISCL is unknown.
HYPOTHESIS/OBJECTIVES: The objective of this study was to measure serum 25 hydroxyvitamin D (25[OH]D) concentrations in cats with IBD or ISCL. Serum 25(OH)D also was measured in healthy cats, and in hospitalized ill cats with nongastrointestinal diseases.
Eighty-four cats were included in the study: 23 in the healthy group, 41 in the hospitalized ill group, and 20 in the IBD/ISCL group.
Retrospective study. Serum samples for vitamin D analysis were frozen at -20°C until serum 25(OH)D was measured by high-performance liquid chromatography (HPLC).
Although there was overlap in serum 25(OH)D concentrations among the 3 groups, serum 25(OH)D concentrations were significantly lower in the cats with IBD or ISCL compared to healthy cats (P < .0001) and hospitalized ill cats (P = .014). In the IBD/ISCL group, there was a significant moderate positive correlation between serum albumin and 25(OH)D concentrations (r = 0.58, P = .018).
The median serum concentration of 25(OH)D was significantly lower in cats with IBD/ISCL than in healthy cats and in hospitalized ill cats. Additional studies are required to elucidate the mechanism of hypovitaminosis D in cats with gastrointestinal diseases, to define the best management strategy to treat this complication, and to investigate its potential prognostic implications.
炎症性肠病（IBD）和肠道小细胞淋巴瘤（ISCL）是猫的常见疾病。IBD和ISCL猫血清中脂溶性维生素（如维生素D）浓度改变的患病率尚不清楚。
假设/目的：本研究的目的是测量IBD或ISCL猫血清25羟维生素D（25[OH]D）浓度。还测量了健康猫以及患有非胃肠道疾病的住院病猫的血清25(OH)D。
84只猫纳入研究：健康组23只，住院病组41只，IBD/ISCL组20只。
回顾性研究。用于维生素D分析的血清样本在-20°C冷冻，直至通过高效液相色谱（HPLC）测量血清25(OH)D。
尽管3组之间血清25(OH)D浓度存在重叠，但IBD或ISCL猫的血清25(OH)D浓度显著低于健康猫（P <.0001）和住院病猫（P =.014）。在IBD/ISCL组中，血清白蛋白与25(OH)D浓度之间存在显著的中度正相关（r = 0.58，P =.018）。
IBD/ISCL猫血清25(OH)D的中位数浓度显著低于健康猫和住院病猫。需要进一步研究以阐明胃肠道疾病猫维生素D缺乏症的机制，确定治疗该并发症的最佳管理策略，并研究其潜在的预后意义。
