Goharifar Hamid, Faezi Seyedeh Tahereh, Paragomi Pedram, Montazeri Ali, Banihashemi Arash Tehrani, Akhlaghkhah Maryam, Abdollahi Bahar Sadeghi, Kamazani Zahra, Akbarian Mahmood
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran,
Rheumatol Int. 2015 Aug;35(8):1409-14. doi: 10.1007/s00296-015-3282-5. Epub 2015 May 14.
SLE is a common autoimmune disease with considerable morbidity. Ramadan fasting is a religious custom Muslims regularly practice. We aimed to evaluate the effect of Ramadan fasting on SLE patients' disease activity, health quality of life and lipid profile. We conducted this case control study as a pilot study in 40 quiescent SLE patients, 21 cases who decided to fast and 19 controls who decided not to have Ramadan fasting between August and November 2009 in lupus unit of Rheumatology Research Center in Tehran University of Medical Sciences, Iran. They were assessed for SLE Disease Activity Index, lipid profile and quality of life with Short-Form 36 (SF-36) Health Survey, 1 day before Ramadan, the day after and 3 months after Ramadan fasting. After 24.1 ± 5.4 (mean ± SD) days of fasting, anti-ds DNA increased for 0.34 ± 0.41 mmol/dL in cases versus 0.07 ± 0.31 in controls (P = 0.026). Likewise C3 increased more dramatically in cases (16.8 ± 17.5 vs. 2.3 ± 13.2 mg/dL, P = 0.006). Three months after fasting, anti-ds DNA was still increased 0.28 ± 0.46 mmol/dL in cases while a 0.02 ± 0.43 mmol/dL drop in controls was detected (P = 0.04). On the contrary, C3 returned to baseline. These changes were not accompanied with significant changes in disease activity and health quality of life. Ramadan fasting had no effect on lipid profile except for delayed total cholesterol decrease in cases in comparison with controls (16.4 ± 29.4 decrease vs. 4.6 ± 23.9 mg/dL decrease, P = 0.018). Ramadan fasting probably has no detrimental effect on SLE patients' disease activity and their quality of life in the quiescent phase of disease.
系统性红斑狼疮（SLE）是一种常见的自身免疫性疾病，发病率较高。斋月禁食是穆斯林经常践行的一种宗教习俗。我们旨在评估斋月禁食对SLE患者疾病活动度、健康生活质量和血脂谱的影响。2009年8月至11月期间，我们在伊朗德黑兰医科大学风湿病研究中心的狼疮科对40例病情静止的SLE患者进行了一项病例对照试点研究，其中21例决定禁食，19例作为对照决定不禁食。在斋月前1天、斋月结束当日及斋月结束3个月后，采用系统性红斑狼疮疾病活动指数、血脂谱以及简短健康调查问卷（SF - 36）对患者的生活质量进行评估。经过24.1±5.4（均值±标准差）天的禁食后，病例组抗双链DNA升高了0.34±0.41mmol/dL，而对照组升高了0.07±0.31mmol/dL（P = 0.026）。同样，病例组补体C3升高更为显著（16.8±17.5 vs. 2.3±13.2mg/dL，P = 0.006）。禁食3个月后，病例组抗双链DNA仍升高0.28±0.46mmol/dL，而对照组下降了0.02±0.43mmol/dL（P = 0.04）。相反，补体C3恢复至基线水平。这些变化并未伴随疾病活动度和健康生活质量的显著改变。斋月禁食对血脂谱无影响，但与对照组相比，病例组总胆固醇下降延迟（分别下降16.4±29.4与4.6±23.9mg/dL，P = 0.018）。斋月禁食可能对疾病静止期的SLE患者的疾病活动度及其生活质量没有不利影响。
