伯氏疏螺旋体p66中的交叉反应表位
Cross-Reactive Epitopes in Borrelia burgdorferi p66.
作者信息
Arnaboldi Paul M, Dattwyler Raymond J
机构信息
Biopeptides Corp., East Setauket, New York, USA, and Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA
Biopeptides Corp., East Setauket, New York, USA, and Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA.
出版信息
Clin Vaccine Immunol. 2015 Jul;22(7):840-3. doi: 10.1128/CVI.00217-15. Epub 2015 May 13.
Abstract
Epitope mapping of the p66 outer membrane protein of Borrelia burgdorferi revealed that the protein contains numerous cross-reactive linear epitopes recognized by serum antibody in the majority of individuals tested, regardless of Lyme disease history, limiting the usefulness of this antigen in Lyme disease serodiagnostic assays.
摘要
伯氏疏螺旋体p66外膜蛋白的表位作图显示，该蛋白含有众多交叉反应性线性表位，在大多数接受检测的个体中，无论其莱姆病病史如何，均可被血清抗体识别，这限制了该抗原在莱姆病血清诊断检测中的实用性。
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