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本文引用的文献

1
Decorin binding proteins A and B in the serodiagnosis of Lyme disease in North America.北美莱姆病血清诊断中的饰胶蛋白聚糖结合蛋白A和B
Clin Vaccine Immunol. 2014 Oct;21(10):1426-36. doi: 10.1128/CVI.00383-14. Epub 2014 Aug 13.
2
Identification of OppA2 linear epitopes as serodiagnostic markers for Lyme disease.鉴定OppA2线性表位作为莱姆病的血清学诊断标志物。
Clin Vaccine Immunol. 2014 May;21(5):704-11. doi: 10.1128/CVI.00792-13. Epub 2014 Mar 12.
3
Outer surface protein C peptide derived from Borrelia burgdorferi sensu stricto as a target for serodiagnosis of early lyme disease.来自狭义伯氏疏螺旋体的外表面蛋白C肽作为早期莱姆病血清学诊断的靶点。
Clin Vaccine Immunol. 2013 Apr;20(4):474-81. doi: 10.1128/CVI.00608-12. Epub 2013 Jan 30.
4
Anti-Borrelia burgdorferi antibody profile in post-Lyme disease syndrome.莱姆病后综合征中的抗伯氏疏螺旋体抗体谱
Clin Vaccine Immunol. 2011 May;18(5):767-71. doi: 10.1128/CVI.00002-11. Epub 2011 Mar 16.
5
P66 porins are present in both Lyme disease and relapsing fever spirochetes: a comparison of the biophysical properties of P66 porins from six Borrelia species.P66孔蛋白存在于莱姆病螺旋体和回归热螺旋体中：六种疏螺旋体属P66孔蛋白生物物理特性的比较
Biochim Biophys Acta. 2010 Jun;1798(6):1197-203. doi: 10.1016/j.bbamem.2010.02.011. Epub 2010 Feb 25.
6
A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi.全基因组蛋白质阵列揭示了人类和白足鼠自然感染伯氏疏螺旋体时有限的一组免疫原。
Infect Immun. 2008 Aug;76(8):3374-89. doi: 10.1128/IAI.00048-08. Epub 2008 May 12.
7
Regulation of expression of the Borrelia burgdorferi beta(3)-chain integrin ligand, P66, in ticks and in culture.伯氏疏螺旋体β(3)链整合素配体P66在蜱及培养物中的表达调控
Infect Immun. 2003 Feb;71(2):1001-7. doi: 10.1128/IAI.71.2.1001-1007.2003.
8
Delineation of Borrelia burgdorferi p66 sequences required for integrin alpha(IIb)beta(3) recognition.确定整合素α(IIb)β(3)识别所需的伯氏疏螺旋体p66序列。
Infect Immun. 2001 May;69(5):3455-9. doi: 10.1128/IAI.69.5.3455-3459.2001.
9
Recognition of multiple antibody epitopes throughout Borrelia burgdorferi p66, a candidate adhesin, in patients with early or late manifestations of Lyme disease.在莱姆病早期或晚期表现患者中对伯氏疏螺旋体p66（一种候选粘附素）上多个抗体表位的识别。
Infect Immun. 2001 Mar;69(3):1953-6. doi: 10.1128/IAI.69.3.1953-1956.2001.
10
Sensitive and specific serodiagnosis of Lyme disease by enzyme-linked immunosorbent assay with a peptide based on an immunodominant conserved region of Borrelia burgdorferi vlsE.通过基于伯氏疏螺旋体vlsE免疫显性保守区的肽进行酶联免疫吸附测定对莱姆病进行灵敏且特异的血清学诊断。
J Clin Microbiol. 1999 Dec;37(12):3990-6. doi: 10.1128/JCM.37.12.3990-3996.1999.

伯氏疏螺旋体p66中的交叉反应表位

Cross-Reactive Epitopes in Borrelia burgdorferi p66.

作者信息

Arnaboldi Paul M, Dattwyler Raymond J

机构信息

Biopeptides Corp., East Setauket, New York, USA, and Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA

Biopeptides Corp., East Setauket, New York, USA, and Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA.

出版信息

Clin Vaccine Immunol. 2015 Jul;22(7):840-3. doi: 10.1128/CVI.00217-15. Epub 2015 May 13.

DOI:10.1128/CVI.00217-15
PMID:25972406
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4478522/
Abstract

Epitope mapping of the p66 outer membrane protein of Borrelia burgdorferi revealed that the protein contains numerous cross-reactive linear epitopes recognized by serum antibody in the majority of individuals tested, regardless of Lyme disease history, limiting the usefulness of this antigen in Lyme disease serodiagnostic assays.

摘要

伯氏疏螺旋体p66外膜蛋白的表位作图显示，该蛋白含有众多交叉反应性线性表位，在大多数接受检测的个体中，无论其莱姆病病史如何，均可被血清抗体识别，这限制了该抗原在莱姆病血清诊断检测中的实用性。