Zhao Frank Z, Wolf Steven E, Nakonezny Paul A, Minhajuddin Abu, Rhodes Ramona L, Paulk M Elizabeth, Phelan Herb A
1 Department of General Surgery, UT Southwestern Medical Center, Parkland Memorial Hospital , Dallas, Texas.
2 Division of Burns/Trauma/Critical Care, Department of Surgery, UT Southwestern Medical Center, Parkland Memorial Hospital , Dallas, Texas.
J Palliat Med. 2015 Aug;18(8):677-81. doi: 10.1089/jpm.2015.0027. Epub 2015 May 14.
A tool to determine the probability of mortality for severely injured geriatric patients is needed.
We sought to create an easily calculated geriatric trauma prognostic score based on parameters available at the bedside to aid in mortality probability determination.
All patients ≥ 65 years of age were identified from our Level I trauma center's registry between January 1, 2000 and December 31, 2013. Measurements included age, Injury Severity score (ISS), units of packed red blood cells (PRBCs) transfused in the first 24 hours, and patients' mortality status at the end of their index hospitalization. As a first step, a logistic regression model with maximum likelihood estimation and robust standard errors was used to estimate the odds of mortality from age, ISS, and PRBCs after dichotomizing PRBCs as yes/no. We then constructed a Geriatric Trauma Outcome (GTO) score that became the sole predictor in the re-specified logistic regression model.
The sample (n = 3841) mean age was 76.5 ± 8.1 years and the mean ISS was 12.4 ± 9.8. In-hospital mortality was 10.8%, and 11.9% received a transfusion by 24 hours. Based on the logistic regression model, the equation with the highest discriminatory ability to estimate probability of mortality was GTO Score = age + (2.5 × ISS) + 22 (if given PRBCs). The area under the receiver operating characteristic curve (AUC) for this model was 0.82. Selected GTO scores and their related probability of dying were: 205 = 75%, 233 = 90%, 252 = 95%, 310 = 99%. The range of GTO scores was 67.5 (survivor) to 275.1 (died).
The GTO model accurately estimates the probability of dying, and can be calculated at bedside by those possessing a working knowledge of ISS calculation.
需要一种工具来确定重伤老年患者的死亡概率。
我们试图基于床边可得参数创建一个易于计算的老年创伤预后评分,以辅助确定死亡概率。
从我们一级创伤中心2000年1月1日至2013年12月31日的登记册中识别出所有年龄≥65岁的患者。测量指标包括年龄、损伤严重程度评分(ISS)、入院后最初24小时输注的浓缩红细胞(PRBC)单位数,以及患者在其索引住院结束时的死亡状态。作为第一步,使用具有最大似然估计和稳健标准误的逻辑回归模型,在将PRBC分为是/否后,估计年龄、ISS和PRBC导致死亡的几率。然后我们构建了一个老年创伤结局(GTO)评分,该评分成为重新指定的逻辑回归模型中的唯一预测因子。
样本(n = 3841)的平均年龄为76.5±8.1岁,平均ISS为12.4±9.8。住院死亡率为10.8%,11.9%的患者在24小时内接受了输血。基于逻辑回归模型,估计死亡概率具有最高辨别能力的方程为:GTO评分 = 年龄 +(2.5×ISS)+ 22(如果输注了PRBC)。该模型的受试者工作特征曲线(AUC)下面积为0.82。选定的GTO评分及其相关死亡概率为:205 = 75%,233 = 90%,252 = 95%,310 = 99%。GTO评分范围为67.5(存活者)至275.1(死亡者)。
GTO模型能准确估计死亡概率,具备ISS计算实用知识的人员可在床边进行计算。