a INRA, UMR 1019, UNH, CRNH Auvergne , Clermont-Ferrand , France.
b Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine , Clermont-Ferrand , France.
Crit Rev Food Sci Nutr. 2017 Jun 13;57(9):1922-1937. doi: 10.1080/10408398.2015.1038377.
Osteoporosis is a chronic and asymptomatic disease characterized by low bone mass and skeletal microarchitectural deterioration, increased risk of fracture, and associated comorbidities most prevalent in the elderly. Due to an increasingly aging population, osteoporosis has become a major health issue requiring innovative disease management. Proteins are important for bone by providing building blocks and by exerting specific regulatory function. This is why adequate protein intake plays a considerable role in both bone development and bone maintenance. More specifically, since an increase in the overall metabolism of collagen can lead to severe dysfunctions and a more fragile bone matrix and because orally administered collagen can be digested in the gut, cross the intestinal barrier, enter the circulation, and become available for metabolic processes in the target tissues, one may speculate that a collagen-enriched diet provides benefits for the skeleton. Collagen-derived products such as gelatin or hydrolyzed collagen (HC) are well acknowledged for their safety from a nutritional point of view; however, what is their impact on bone biology? In this manuscript, we critically review the evidence from literature for an effect of HC on bone tissues in order to determine whether HC may represent a relevant alternative in the design of future nutritional approaches to manage osteoporosis prevention.
骨质疏松症是一种慢性、无症状的疾病,其特征是骨量低和骨骼微观结构恶化,骨折风险增加,以及与老年人最相关的合并症。由于人口老龄化日益加剧,骨质疏松症已成为一个重大的健康问题,需要创新的疾病管理。蛋白质通过提供构建块和发挥特定的调节功能对骨骼很重要。这就是为什么足够的蛋白质摄入对骨骼发育和维持都起着相当大的作用。更具体地说,由于胶原整体代谢的增加可能导致严重的功能障碍和更脆弱的骨基质,并且由于口服胶原可以在肠道中被消化,穿过肠屏障,进入循环,并可用于靶组织中的代谢过程,人们可能会推测富含胶原的饮食对骨骼有益。从营养角度来看,胶原衍生产品(如明胶或水解胶原[HC])的安全性是得到充分认可的;然而,它们对骨骼生物学有什么影响呢?在本文中,我们批判性地回顾了文献中的证据,以确定 HC 是否可能对骨组织产生影响,从而确定 HC 是否可能成为未来管理骨质疏松症预防的营养方法设计中的一个相关替代方案。