Department of Environmental and Health Sciences, Northern Vermont University, Johnson, VT 05661, USA.
Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Nutrients. 2020 Jul 16;12(7):2104. doi: 10.3390/nu12072104.
Chronic pain is a public health concern and additional treatment options are essential. Inadequate magnesium intake has been associated with chronic pain in some populations. We sought to examine the relationship between dietary magnesium intake and chronic pain in a large, representative cohort of U.S. adults (NHANES). Of the 13,434 eligible adults surveyed between 1999 and 2004, 14.5% reported chronic pain while 66% reported inadequate magnesium intake. The univariate analysis showed a protective effect of increased magnesium intake adjusted for body weight (odds ratio 0.92; 95%; CI 0.88, 0.95; < 0.001). It remained so even after correcting for socioeconomic and clinical factors as well as total calorie intake (odds ratio 0.93; 95% CI 0.87, 0.99; = 0.02). The association was stronger in females (odds ratio 0.91; 95% CI 0.85, 0.98; = 0.01) than males (odds ratio 0.96; 95% CI 0.89, 1.04; = 0.32). The potential protective effect of magnesium intake on chronic pain warrants further investigation.
慢性疼痛是一个公共健康问题，因此需要更多的治疗选择。在一些人群中，镁摄入不足与慢性疼痛有关。我们试图在美国成年人（NHANES）的一个大型代表性队列中研究饮食镁摄入与慢性疼痛之间的关系。在 1999 年至 2004 年间接受调查的 13434 名合格成年人中，14.5%报告有慢性疼痛，而 66%报告镁摄入不足。单变量分析显示，调整体重后，镁摄入量增加具有保护作用（比值比 0.92；95%置信区间 0.88，0.95；<0.001）。即使在校正社会经济和临床因素以及总热量摄入后，这种情况仍然存在（比值比 0.93；95%置信区间 0.87，0.99；=0.02）。这种关联在女性中更强（比值比 0.91；95%置信区间 0.85，0.98；=0.01），而在男性中则较弱（比值比 0.96；95%置信区间 0.89，1.04；=0.32）。镁摄入对慢性疼痛的潜在保护作用值得进一步研究。
