缺血性中风与修复：研究及组织工程治疗的当前趋势
Ischemic stroke and repair: current trends in research and tissue engineering treatments.
作者信息
Wang Jian, Yang Wen, Xie Hongjian, Song Yu, Li Yongkui, Wang Lin
机构信息
Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China ; Medical Research Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Regen Med Res. 2014 Feb 3;2(1):3. doi: 10.1186/2050-490X-2-3. eCollection 2014 Dec.
Stroke, the third leading cause of mortality, is usually associated with severe disabilities, high recurrence rate and other poor outcomes. Currently, there are no long-term effective treatments for stroke. Cell and cytokine therapies have been explored previously. However, the therapeutic outcomes are often limited by poor survival of transplanted cells, uncontrolled cell differentiation, ineffective engraftment with host tissues and non-sustained delivery of growth factors. A tissue-engineering approach provides an alternative for treating ischemic stroke. The key design considerations for the tissue engineering approach include: choice of scaffold materials, choice of cells and cytokines and delivery methods. Here, we review current cell and biomaterial based therapies available for ischemic stroke, with a special focus on tissue-engineering strategies for regeneration of stroke-affected neuronal tissue.
中风是第三大致死原因，通常与严重残疾、高复发率及其他不良后果相关。目前，尚无针对中风的长期有效治疗方法。此前已对细胞和细胞因子疗法进行了探索。然而，治疗效果常常受到移植细胞存活率低、细胞分化不受控、与宿主组织的植入效果不佳以及生长因子的递送不持续等因素的限制。组织工程方法为治疗缺血性中风提供了一种替代方案。组织工程方法的关键设计考量包括：支架材料的选择、细胞和细胞因子的选择以及递送方法。在此，我们综述了目前可用于缺血性中风的基于细胞和生物材料的疗法，特别关注中风影响的神经元组织再生的组织工程策略。
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