Ulusu Nuriye Nuray
School of Medicine, Koç University, Rumelifeneri yolu, Sarıyer, Istanbul, Turkey,
J Mol Evol. 2015 Jun;80(5-6):251-7. doi: 10.1007/s00239-015-9681-0. Epub 2015 May 19.
This review paper discusses the reciprocal kinetic behaviours of enzymes and the evolution of structure-function dichotomy. Kinetic mechanisms have evolved in response to alterations in ecological and metabolic conditions. The kinetic mechanisms of single-substrate mono-substrate enzyme reactions are easier to understand and much simpler than those of bi-bi substrate enzyme reactions. The increasing complexities of kinetic mechanisms, as well as the increasing number of enzyme subunits, can be used to shed light on the evolution of kinetic mechanisms. Enzymes with heterogeneous kinetic mechanisms attempt to achieve specific products to subsist. In many organisms, kinetic mechanisms have evolved to aid survival in response to changing environmental factors. Enzyme promiscuity is defined as adaptation to changing environmental conditions, such as the introduction of a toxin or a new carbon source. Enzyme promiscuity is defined as adaptation to changing environmental conditions, such as the introduction of a toxin or a new carbon source. Enzymes with broad substrate specificity and promiscuous properties are believed to be more evolved than single-substrate enzymes. This group of enzymes can adapt to changing environmental substrate conditions and adjust catalysing mechanisms according to the substrate's properties, and their kinetic mechanisms have evolved in response to substrate variability.
这篇综述论文讨论了酶的相互动力学行为以及结构 - 功能二分法的演变。动力学机制是为响应生态和代谢条件的变化而进化的。单底物单底物酶反应的动力学机制比双底物酶反应的更容易理解且简单得多。动力学机制复杂性的增加以及酶亚基数量的增加，可用于阐明动力学机制的进化。具有异质动力学机制的酶试图产生特定产物以维持生存。在许多生物体中，动力学机制已经进化以帮助在不断变化的环境因素中生存。酶的多效性被定义为对环境变化的适应，例如引入毒素或新的碳源。酶的多效性被定义为对环境变化的适应，例如引入毒素或新的碳源。具有广泛底物特异性和多效性的酶被认为比单底物酶进化程度更高。这一类酶能够适应不断变化的环境底物条件，并根据底物的性质调整催化机制，其动力学机制是为响应底物变异性而进化的。
