Fedda Faysal, Boulos Fouad, Sabri Alain
M.D. (Resident).
M.D. (Assistant Professor).
Int Arch Otorhinolaryngol. 2013 Apr;17(2):218-21. doi: 10.7162/S1809-97772013000200017.
Chondro-osseous respiratory epithelial adenomatoid hamartoma (COREAH) is a benign lesion of the nose and sinuses that is extremely rare, with only 2 cases reported in the literature to date.
We present herein the third reported case of COREAH, in a 38-year-old woman who presented with left nasal obstruction and a mass in her left nasal cavity. The mass was completely resected endoscopically. Microscopic examination showed hamartomatous proliferation of respiratory-type glands with mucinous metaplasia admixed with numerous spicules of mature bone, characteristic of COREAH.
COREAH is a benign hamartomatous proliferation of respiratory epithelium, submucosal glands, and chondro-osseous mesenchyme. The clinical differential diagnoses for such lesions include glandular hamartoma, inflammatory polyp, inverted papilloma, and low-grade sinonasal adenocarcinoma. Recognition of this lesion as benign despite its potentially worrisome radiographic appearance is important to avoid an unnecessarily radical surgical procedure.
软骨-骨化性呼吸上皮腺样错构瘤（COREAH）是一种极其罕见的鼻和鼻窦良性病变，迄今为止文献中仅报道过2例。
我们在此报告第3例COREAH，患者为一名38岁女性，表现为左侧鼻塞及左侧鼻腔肿物。该肿物经内镜完全切除。显微镜检查显示呼吸型腺体错构瘤样增生，伴有黏液化生，并混有大量成熟骨针，这是COREAH的特征。
COREAH是呼吸上皮、黏膜下腺体及软骨-骨化间充质的良性错构瘤样增生。此类病变的临床鉴别诊断包括腺性错构瘤、炎性息肉、内翻性乳头状瘤及低级别鼻窦腺癌。尽管该病变的影像学表现可能令人担忧，但认识到其为良性病变对于避免不必要的根治性手术很重要。
