几内亚科纳克里Donka国家医院收治的埃博拉病毒病患者的高生存率及相关因素
High survival rates and associated factors among ebola virus disease patients hospitalized at donka national hospital, conakry, Guinea.
作者信息
Qureshi Adnan I, Chughtai Morad, Bah Elhadj Ibrahima, Barry Moumié, Béavogui Kézély, Loua Tokpagnan Oscar, Malik Ahmed A
机构信息
Zeenat Qureshi Stroke Institute, St. Cloud Minnesota;
Department of Infectious and Parasitic Diseases, Donka National Hospital, Conakry, Guinea;
出版信息
J Vasc Interv Neurol. 2015 Feb;8(1.5):S4-S11.
BACKGROUND
Anecdotal reports suggesting that survival rates among hospitalized patients with Ebola virus disease in Guinea are higher than the 29.2% rate observed in the current epidemic in West Africa.
METHODS
Survival after symptom onset was determined using Kaplan Meier survival methods among patients with confirmed Ebola virus disease treated in Conakry, Guinea from March 25, 2014, to August 5, 2014. We analyzed the relationship between survival and patient factors, including demographics and clinical features.
RESULTS
Of the 70 patients analyzed [mean age ± standard deviation (SD), 34 ± 14.1; 44 were men], 42 were discharged alive with a survival rate among hospitalized patients of 60% (95% confidence interval, 41.5-78.5%). The survival rate was 28 (71.8%) among 39 patients under 34 years of age, and 14 (46.7%) among 30 patients aged 35 years or greater (p = 0.034). The rates of myalgia (3 of 42 versus 7 of 28, p = 0.036) and hiccups (1 of 42 versus 5 of 28, p = 0.023) were significantly lower among patients who survived.
CONCLUSIONS
Our results provide insights into a cohort of hospitalized patients with Ebola virus disease in whom survival is prominently higher than seen in other cohorts of hospitalized patients.
背景
有传闻称，几内亚埃博拉病毒病住院患者的存活率高于西非当前疫情中观察到的29.2%的存活率。
方法
采用Kaplan-Meier生存方法，确定2014年3月25日至2014年8月5日在几内亚科纳克里接受治疗的确诊埃博拉病毒病患者症状出现后的存活率。我们分析了存活率与患者因素之间的关系，包括人口统计学和临床特征。
结果
在分析的70例患者中（平均年龄±标准差[SD]，34±14.1；44例为男性），42例患者存活出院，住院患者的存活率为60%（95%置信区间，41.5-78.5%）。34岁以下的39例患者中，28例（71.8%）存活；35岁及以上的30例患者中，14例（46.7%）存活（p=0.034）。存活患者的肌痛发生率（42例中的3例对28例中的7例，p=0.036）和打嗝发生率（42例中的1例对28例中的5例，p=0.023）显著较低。
结论
我们的结果为一组埃博拉病毒病住院患者提供了见解，这些患者的存活率明显高于其他住院患者群体。
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