Zhang Shu, Mo Fei, Luo Zhaoxun, Huang Jian, Sun Chaoqin, Zhang Ran
Guiyang medical college, Guiyang, 550004, China.
Affiliated hospital of Guiyang Medical College, Guiyang, 550004, China.
PLoS One. 2015 May 18;10(5):e0126584. doi: 10.1371/journal.pone.0126584. eCollection 2015.
The antibacterial and anti-inflammatory activities, and protective effects of extracts (flavonoid glycosides) of Polygonum capitatum were investigated to detect the evidence for the utilization of the herb in the clinical therapy of gastritis caused by H. pylori. A mouse gastritis model was established using H. pylori. According to treating methods, model mice were random assigned into a model group (MG group), a triple antibiotics group (TG group, clarithromycin, omeprazole and amoxicillin), low/middle/high concentrations of flavonoid glycosides groups (LF, MF and HF groups) and low/middle/high concentrations of flavonoid glycosides and amoxicillin groups (LFA, MFA and HFA groups). A group with pathogen-free mice was regarded as a control group (CG group). The eradicate rates of H. pylori were 100%, 93%, 89% in TG, MFA and HF groups. The serum levels of IFN-gamma and gastrin were higher in a MG group than those from all other groups (P < 0.05). The serum levels of IFN-gamma and gastrin were reduced significantly in LF, MF and HF groups (P < 0.05) while little changes were observed in LFA, MFA and HFA groups. In contrast, the serum levels of IL-4 were lower and higher in MG and CG groups compared with other groups (P<0.05). The serum levels of IL-4 were increased significantly in LF, MF and HF groups (P < 0.05) while little changes were found in LFA, MFA and HFA groups. According to pathological scores, flavonoid glycosides therapy showed better protection for gastric injuries than the combination of flavonoid glycoside and amoxicillin (P < 0.05). The results suggested that flavonoid glycoside has repairing functions for gastric injuries. The results suggest that the plant can treat gastritis and protect against gastric injuries. The flavonoid glycosides from Polygonum capitatum should be developed as a potential drug for the therapy of gastritis caused by H. pylori.
研究了头花蓼提取物（黄酮苷）的抗菌、抗炎活性及保护作用，以探寻该草药用于幽门螺杆菌引起的胃炎临床治疗的依据。采用幽门螺杆菌建立小鼠胃炎模型。根据治疗方法，将模型小鼠随机分为模型组（MG组）、三联抗生素组（TG组，克拉霉素、奥美拉唑和阿莫西林）、低/中/高浓度黄酮苷组（LF、MF和HF组）以及低/中/高浓度黄酮苷与阿莫西林组（LFA、MFA和HFA组）。将无病原体小鼠组作为对照组（CG组）。TG、MFA和HF组的幽门螺杆菌根除率分别为100%、93%、89%。MG组的血清干扰素-γ和胃泌素水平高于其他所有组（P<0.05）。LF、MF和HF组的血清干扰素-γ和胃泌素水平显著降低（P<0.05），而LFA、MFA和HFA组变化不大。相比之下，MG组和CG组的血清白细胞介素-4水平与其他组相比更低和更高（P<0.05）。LF、MF和HF组的血清白细胞介素-4水平显著升高（P<0.05），而LFA、MFA和HFA组变化不大。根据病理评分，黄酮苷治疗对胃损伤的保护作用优于黄酮苷与阿莫西林联合治疗（P<0.05）。结果表明黄酮苷对胃损伤具有修复作用。结果表明该植物可治疗胃炎并预防胃损伤。头花蓼中的黄酮苷应开发为治疗幽门螺杆菌引起的胃炎的潜在药物。
