Ma Lu, Chu Wei-Ming, Zhu Jiang, Wu Yu-Nong, Wang Zi-Lu
Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China ; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, China.
Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China.
Arch Med Sci. 2015 Apr 25;11(2):267-73. doi: 10.5114/aoms.2015.50961. Epub 2015 Apr 23.
To investigate the association of the interleukin-1β (IL-1β) (3953/4) C→T polymorphism with chronic periodontitis (CP) in Asians.
Systematic searches of electronic databases and hand searching of references were performed, including PubMed, Embase, the Cochrane Library, and the Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations. Publication bias was tested by Egger's test. Sensitivity analysis was conducted by limiting the meta-analysis studies conforming to Hardy-Weinberg equilibrium (HWE). Data analyses were carried out using RevMan 6.0.
A meta-analysis was performed on 20 published case-control studies, including 1,656 CP cases and 1,498 healthy controls. The pooled OR was 1.60 (95% CI = 1.02-2.52, p = 0.04) for the T allele carriers (TT + CT) compared with CC and 1.60 (95% CI = 1.06-2.42, p = 0.02) for T vs. C. Subgroup analysis by country revealed significant risks of CP among Indians carrying the T allele (TT vs. CC: OR = 3.88, 95% CI = 1.77-8.50, p = 0.0007).
The analysis showed that IL-1β (3953/4) C→T polymorphism probably increases the risk of CP in Asians, and the IL-1β+3954 TT genotype may be associated with a strongly increased risk of CP in Indians, but not in Chinese.
研究亚洲人群中白细胞介素-1β（IL-1β）（3953/4）C→T多态性与慢性牙周炎（CP）的相关性。
对电子数据库进行系统检索，并手工检索参考文献，包括PubMed、Embase、Cochrane图书馆和中国知网（CNKI）。采用比值比（OR）及95%置信区间（CI）评估关联强度。采用Egger检验检测发表偏倚。通过限制符合哈迪-温伯格平衡（HWE）的荟萃分析研究进行敏感性分析。使用RevMan 6.0进行数据分析。
对20项已发表的病例对照研究进行荟萃分析，包括1656例CP病例和1498例健康对照。与CC基因型相比，T等位基因携带者（TT + CT）的合并OR为1.60（95%CI = 1.02 - 2.52，p = 0.04），T与C相比的合并OR为1.60（95%CI = 1.06 - 2.42，p = 0.02）。按国家进行的亚组分析显示，携带T等位基因的印度人患CP的风险显著增加（TT与CC相比：OR = 3.88，95%CI = 1.77 - 8.50，p = 0.0007）。
分析表明，IL-1β（3953/4）C→T多态性可能增加亚洲人患CP的风险，IL-1β + 3954 TT基因型可能与印度人患CP的风险大幅增加有关，但与中国人无关。
